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In Vitro and In Vivo Antiurolithic Effect of Betulinic Acid Obtained from Citharexylum mirianthum.
Mariano LNB, Vequi G, da Silva RCV, Macarini AF, Dada A, Costa TM, Omena MM, Pereira CRP, Cechinel-Filho V, Niero R, de Souza P. Mariano LNB, et al. Plants (Basel). 2024 Aug 1;13(15):2141. doi: 10.3390/plants13152141. Plants (Basel). 2024. PMID: 39124259 Free PMC article.
The study aimed to investigate the potential antiurolithic effects of extracts, fractions, and betulinic acid (BA) from Citharexylum mirianthum. In vitro analysis involved precipitating calcium oxalate (CaOx) crystals in urine. ...
The study aimed to investigate the potential antiurolithic effects of extracts, fractions, and betulinic acid (BA) from Citharexylum …
3-Demethyl-2-geranyl-4-prenylbellidifoline, a natural xanthone with diuretic and kidney protective properties.
Mariano LNB, Boeing T, Filho VC, Niero R, da Silva LM, de Souza P. Mariano LNB, et al. J Pharm Pharmacol. 2024 Jan 27;76(2):106-114. doi: 10.1093/jpp/rgad123. J Pharm Pharmacol. 2024. PMID: 38166170
CONCLUSION: Together, this study displayed the prolonged diuretic action of DGP and its natriuretic, Ca2+-sparing, and antiurolytic effects. The antioxidative and anti-inflammatory effects of DGP were evidenced in SHR kidneys, opening perspectives for further studie …
CONCLUSION: Together, this study displayed the prolonged diuretic action of DGP and its natriuretic, Ca2+-sparing, and antiurolytic effec
Vasodilation and Blood Pressure-Lowering Effect of 3-Demethyl-2-Geranyl-4-Prenylbellidifoline, a Xanthone Obtained from Garcinia achachairu, in Hypertensive Rats.
Mariano LNB, da Silva RCV, Niero R, Cechinel Filho V, da Silva-Santos JE, de Souza P. Mariano LNB, et al. Plants (Basel). 2024 Feb 15;13(4):528. doi: 10.3390/plants13040528. Plants (Basel). 2024. PMID: 38498544 Free PMC article.
The present study expands its actions on the cardiovascular system by evaluating its vasorelaxant and blood pressure-lowering effects in spontaneously hypertensive rats (SHRs). Aortic endothelium-intact (E+) preparations of SHRs pre-contracted by phenylephrine and exposed …
The present study expands its actions on the cardiovascular system by evaluating its vasorelaxant and blood pressure-lowering effects
Comparative Analysis of the Protective Effect of Naringenin on Cardiovascular Parameters of Normotensive and Hypertensive Rats Subjected to the Myocardial Infarction Model.
Dada A, da Silva RCV, Zanovello M, Moser JC, Orengo SLD, Cavichiolo MO, Bidinha ER, Boeing T, Cechinel-Filho V, de Souza P. Dada A, et al. Pharmaceuticals (Basel). 2024 Oct 4;17(10):1324. doi: 10.3390/ph17101324. Pharmaceuticals (Basel). 2024. PMID: 39458965 Free PMC article.
Among therapeutic approaches, bioactives from medicinal plants emerge as promising for the development of new medicines. Objectives: This study explored the effects of naringenin (NAR 100 mg/kg), a flavonoid found in citrus fruits, in normotensive (NTR) and spontaneously h …
Among therapeutic approaches, bioactives from medicinal plants emerge as promising for the development of new medicines. Objectives: This st …