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SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor.
Alnouri MW, Roquid KA, Bonnavion R, Cho H, Heering J, Kwon J, Jäger Y, Wang S, Günther S, Wettschureck N, Geisslinger G, Gurke R, Müller CE, Proschak E, Offermanns S. Alnouri MW, et al. Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2407130121. doi: 10.1073/pnas.2407130121. Epub 2024 Oct 4. Proc Natl Acad Sci U S A. 2024. PMID: 39365815 Free PMC article.
RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions.
Weiss LM, Warwick T, Zehr S, Günther S, Wolf S, Schmachtel T, Izquierdo Ponce J, Pálfi K, Teichmann T, Schneider A, Stötzel J, Knapp S, Weigert A, Savai R, Rieger MA, Oellerich T, Wittig I, Oo JA, Brandes RP, Leisegang MS. Weiss LM, et al. Commun Biol. 2024 Sep 13;7(1):1131. doi: 10.1038/s42003-024-06794-2. Commun Biol. 2024. PMID: 39271940 Free PMC article.
The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors.
Teichmann T, Pflüger-Müller B, Giménez VMM, Sailer F, Dirks H, Zehr S, Warwick T, Brettner F, Munoz-Tello P, Zimmer A, Tegeder I, Thomas D, Gurke R, Günther S, Heering J, Proschak E, Geisslinger G, Bibli IS, Heringdorf DMZ, Manucha W, Windbergs M, Knapp S, Weigert A, Leisegang MS, Kojetin D, Brandes RP. Teichmann T, et al. Br J Pharmacol. 2024 Nov 19. doi: 10.1111/bph.17366. Online ahead of print. Br J Pharmacol. 2024. PMID: 39563075