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Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies.
Khan AO, Rodriguez-Romera A, Reyat JS, Olijnik AA, Colombo M, Wang G, Wen WX, Sousos N, Murphy LC, Grygielska B, Perrella G, Mahony CB, Ling RE, Elliott NE, Karali CS, Stone AP, Kemble S, Cutler EA, Fielding AK, Croft AP, Bassett D, Poologasundarampillai G, Roy A, Gooding S, Rayes J, Machlus KR, Psaila B. Khan AO, et al. Cancer Discov. 2023 Feb 6;13(2):364-385. doi: 10.1158/2159-8290.CD-22-0199. Cancer Discov. 2023. PMID: 36351055 Free PMC article.
A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis.
Li R, Colombo M, Wang G, Rodriguez-Romera A, Benlabiod C, Jooss NJ, O'Sullivan J, Brierley CK, Clark SA, Pérez Sáez JM, Fernández PA, Schoof EM, Porse B, Meng Y, Khan AO, Wen S, Dong P, Zhou W, Sousos N, Murphy L, Clarke M, Olijnik AA, Wong ZC, Karali CS, Sirinukunwattana K, Ryou H, Norfo R, Cheng Q, Carrelha J, Ren Z, Thongjuea S, Rathinam VA, Krishnan A, Royston D, Rabinovich GA, Mead AJ, Psaila B. Li R, et al. Sci Transl Med. 2024 Oct 9;16(768):eadj7552. doi: 10.1126/scitranslmed.adj7552. Epub 2024 Oct 9. Sci Transl Med. 2024. PMID: 39383242 Free PMC article.