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NaCl enhances CD8+ T cell effector functions in cancer immunotherapy.
Scirgolea C, Sottile R, De Luca M, Susana A, Carnevale S, Puccio S, Ferrari V, Lise V, Contarini G, Scarpa A, Scamardella E, Feno S, Camisaschi C, De Simone G, Basso G, Giuliano D, Mazza EMC, Gattinoni L, Roychoudhuri R, Voulaz E, Di Mitri D, Simonelli M, Losurdo A, Pozzi D, Tsui C, Kallies A, Timo S, Martano G, Barberis E, Manfredi M, Rescigno M, Jaillon S, Lugli E. Scirgolea C, et al. Nat Immunol. 2024 Oct;25(10):1845-1857. doi: 10.1038/s41590-024-01923-9. Epub 2024 Aug 28. Nat Immunol. 2024. PMID: 39198631
The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate.
Weisshaar N, Ma S, Ming Y, Madi A, Mieg A, Hering M, Zettl F, Mohr K, Ten Bosch N, Stichling D, Buettner M, Poschet G, Klinke G, Schulz M, Kunze-Rohrbach N, Kerber C, Klein IM, Wu J, Wang X, Cui G. Weisshaar N, et al. Nat Immunol. 2023 Nov;24(11):1921-1932. doi: 10.1038/s41590-023-01636-5. Epub 2023 Oct 9. Nat Immunol. 2023. PMID: 37813964 Free PMC article.