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SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake.
Albalawy WN, Youm EB, Shipman KE, Trull KJ, Baty CJ, Long KR, Rbaibi Y, Wang XP, Fagunloye OG, White KA, Jurczak MJ, Kashlan OB, Weisz OA. Albalawy WN, et al. Am J Physiol Renal Physiol. 2024 Jun 1;326(6):F1041-F1053. doi: 10.1152/ajprenal.00005.2024. Epub 2024 Apr 25. Am J Physiol Renal Physiol. 2024. PMID: 38660713
Brown-Norway chromosome 1 mitigates the upregulation of proinflammatory pathways in mTAL cells and subsequent age-related CKD in Dahl SS/JrHsdMcwi rats.
Chivers JM, Whiles SA, Miles CB, Biederman BE, Ellison MF, Lovingood CW, Wright MH, Hoover DB, Raafey MA, Youngberg GA, Venkatachalam MA, Zheleznova NN, Yang C, Liu P, Kriegel AJ, Cowley AW, O'Connor PM, Picken MM, Polichnowski AJ. Chivers JM, et al. Am J Physiol Renal Physiol. 2023 Feb 1;324(2):F193-F210. doi: 10.1152/ajprenal.00145.2022. Epub 2022 Dec 8. Am J Physiol Renal Physiol. 2023. PMID: 36475869 Free PMC article.