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Page 1
Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors PRPF8 and RBMX as novel candidate actionable targets.
Alors-Pérez E, Blázquez-Encinas R, Moreno-Montilla MT, García-Vioque V, Jiménez-Vacas JM, Mafficini A, González-Borja I, Luchini C, Sánchez-Hidalgo JM, Sánchez-Frías ME, Pedraza-Arevalo S, Romero-Ruiz A, Lawlor RT, Viúdez A, Gahete MD, Scarpa A, Arjona-Sánchez Á, Luque RM, Ibáñez-Costa A, Castaño JP. Alors-Pérez E, et al. Mol Oncol. 2024 Oct;18(10):2524-2540. doi: 10.1002/1878-0261.13658. Epub 2024 May 24. Mol Oncol. 2024. PMID: 38790138 Free PMC article.
SF3B1 inhibition disrupts malignancy and prolongs survival in glioblastoma patients through BCL2L1 splicing and mTOR/ß-catenin pathways imbalances.
Fuentes-Fayos AC, Pérez-Gómez JM, G-García ME, Jiménez-Vacas JM, Blanco-Acevedo C, Sánchez-Sánchez R, Solivera J, Breunig JJ, Gahete MD, Castaño JP, Luque RM. Fuentes-Fayos AC, et al. J Exp Clin Cancer Res. 2022 Jan 27;41(1):39. doi: 10.1186/s13046-022-02241-4. J Exp Clin Cancer Res. 2022. PMID: 35086552 Free PMC article.
Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness Features.
Vázquez-Borrego MC, Fuentes-Fayos AC, Venegas-Moreno E, Rivero-Cortés E, Dios E, Moreno-Moreno P, Madrazo-Atutxa A, Remón P, Solivera J, Wildemberg LE, Kasuki L, López-Fernández JM, Gadelha MR, Gálvez-Moreno MA, Soto-Moreno A, Gahete MD, Castaño JP, Luque RM. Vázquez-Borrego MC, et al. Cancers (Basel). 2019 Sep 26;11(10):1439. doi: 10.3390/cancers11101439. Cancers (Basel). 2019. PMID: 31561558 Free PMC article.
Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer.
Jiménez-Vacas JM, Gómez-Gómez E, Montero-Hidalgo AJ, Herrero-Aguayo V, L-López F, Sánchez-Sánchez R, Guler I, Blanca A, Méndez-Vidal MJ, Carrasco J, Lopez-Miranda J, Requena-Tapia MJ, Castaño JP, Gahete MD, Luque RM. Jiménez-Vacas JM, et al. J Clin Med. 2019 Nov 22;8(12):2056. doi: 10.3390/jcm8122056. J Clin Med. 2019. PMID: 31766715 Free PMC article.
Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study.
Del Río-Moreno M, Luque RM, Rangel-Zúñiga OA, Alors-Pérez E, Alcalá-Diaz JF, Roncero-Ramos I, Camargo A, Gahete MD, López-Miranda J, Castaño JP. Del Río-Moreno M, et al. Nutrients. 2020 Nov 17;12(11):3528. doi: 10.3390/nu12113528. Nutrients. 2020. PMID: 33212780 Free PMC article. Clinical Trial.