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Carbohydrate vaccines in cancer: immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man.
Slovin SF, Ragupathi G, Adluri S, Ungers G, Terry K, Kim S, Spassova M, Bornmann WG, Fazzari M, Dantis L, Olkiewicz K, Lloyd KO, Livingston PO, Danishefsky SJ, Scher HI. Slovin SF, et al. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5710-5. doi: 10.1073/pnas.96.10.5710. Proc Natl Acad Sci U S A. 1999. PMID: 10318949 Free PMC article. Clinical Trial.
Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens.
Wang ZG, Williams LJ, Zhang XF, Zatorski A, Kudryashov V, Ragupathi G, Spassova M, Bornmann W, Slovin SF, Scher HI, Livingston PO, Lloyd KO, Danishefsky SJ. Wang ZG, et al. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2719-24. doi: 10.1073/pnas.97.6.2719. Proc Natl Acad Sci U S A. 2000. PMID: 10716997 Free PMC article.
Vaccines prepared with sialyl-Tn and sialyl-Tn trimers using the 4-(4-maleimidomethyl)cyclohexane-1-carboxyl hydrazide linker group result in optimal antibody titers against ovine submaxillary mucin and sialyl-Tn-positive tumor cells.
Ragupathi G, Howard L, Cappello S, Koganty RR, Qiu D, Longenecker BM, Reddish MA, Lloyd KO, Livingston PO. Ragupathi G, et al. Cancer Immunol Immunother. 1999 Apr;48(1):1-8. doi: 10.1007/s002620050542. Cancer Immunol Immunother. 1999. PMID: 10235483 Free PMC article.