CA080942/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2003	1
2005	2
2006	1
2007	3
2008	3
2009	2
2010	2
2013	1
2024	0

1

Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity.

Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ. Yun CH, et al. Cancer Cell. 2007 Mar;11(3):217-27. doi: 10.1016/j.ccr.2006.12.017. Cancer Cell. 2007. PMID: 17349580 Free PMC article.

2

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.

Yun CH, Mengwasser KE, Toms AV, Woo MS, Greulich H, Wong KK, Meyerson M, Eck MJ. Yun CH, et al. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2070-5. doi: 10.1073/pnas.0709662105. Epub 2008 Jan 28. Proc Natl Acad Sci U S A. 2008. PMID: 18227510 Free PMC article.

3

Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer.

Eck MJ, Yun CH. Eck MJ, et al. Biochim Biophys Acta. 2010 Mar;1804(3):559-66. doi: 10.1016/j.bbapap.2009.12.010. Epub 2009 Dec 22. Biochim Biophys Acta. 2010. PMID: 20026433 Free PMC article. Review.

4

Structure and ubiquitination-dependent activation of TANK-binding kinase 1.

Tu D, Zhu Z, Zhou AY, Yun CH, Lee KE, Toms AV, Li Y, Dunn GP, Chan E, Thai T, Yang S, Ficarro SB, Marto JA, Jeon H, Hahn WC, Barbie DA, Eck MJ. Tu D, et al. Cell Rep. 2013 Mar 28;3(3):747-58. doi: 10.1016/j.celrep.2013.01.033. Epub 2013 Feb 28. Cell Rep. 2013. PMID: 23453972 Free PMC article.

5

Structural basis for the autoinhibition of focal adhesion kinase.

Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ. Lietha D, et al. Cell. 2007 Jun 15;129(6):1177-87. doi: 10.1016/j.cell.2007.05.041. Cell. 2007. PMID: 17574028 Free PMC article.

6

A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.

Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ. Kim PW, et al. Science. 2003 Sep 19;301(5640):1725-8. doi: 10.1126/science.1085643. Science. 2003. PMID: 14500983

7

Crystal structure of the FERM domain of focal adhesion kinase.

Ceccarelli DF, Song HK, Poy F, Schaller MD, Eck MJ. Ceccarelli DF, et al. J Biol Chem. 2006 Jan 6;281(1):252-9. doi: 10.1074/jbc.M509188200. Epub 2005 Oct 12. J Biol Chem. 2006. PMID: 16221668 Free article.

8

Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.

Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM. Blair JA, et al. Nat Chem Biol. 2007 Apr;3(4):229-38. doi: 10.1038/nchembio866. Epub 2007 Mar 4. Nat Chem Biol. 2007. PMID: 17334377

9

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.

Zhou W, Ercan D, Chen L, Yun CH, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE, Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, Jänne PA. Zhou W, et al. Nature. 2009 Dec 24;462(7276):1070-4. doi: 10.1038/nature08622. Nature. 2009. PMID: 20033049 Free PMC article.

10

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog.

Boggon TJ, Li Y, Manley PW, Eck MJ. Boggon TJ, et al. Blood. 2005 Aug 1;106(3):996-1002. doi: 10.1182/blood-2005-02-0707. Epub 2005 Apr 14. Blood. 2005. PMID: 15831699 Free PMC article.

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