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Year Number of Results
2017 4
2018 52
2019 97
2020 113
2021 137
2022 88
2023 43
2024 253
2025 39

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755 results

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Page 1
ESR1 mutations in breast cancer.
Dustin D, Gu G, Fuqua SAW. Dustin D, et al. Cancer. 2019 Nov 1;125(21):3714-3728. doi: 10.1002/cncr.32345. Epub 2019 Jul 18. Cancer. 2019. PMID: 31318440 Free PMC article. Review.
The acquisition of ligand-independent ESR1 mutations during aromatase inhibitor therapy in metastatic estrogen receptor (ER)-positive breast cancer is a common mechanism of hormonal therapy resistance. Preclinical and clinical studies have demonstrated that ESR1 mutations …
The acquisition of ligand-independent ESR1 mutations during aromatase inhibitor therapy in metastatic estrogen receptor (ER)-positive breast …
Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action.
Safe S, Kothari J, Hailemariam A, Upadhyay S, Davidson LA, Chapkin RS. Safe S, et al. Int J Mol Sci. 2023 Jan 31;24(3):2706. doi: 10.3390/ijms24032706. Int J Mol Sci. 2023. PMID: 36769029 Free PMC article. Review.
In addition, there is also evidence that higher coffee consumption is associated with lower rates of colon and rectal cancer, as well as breast, endometrial, and other cancers, although for some of these cancers, the results are conflicting. ...Further elucid …
In addition, there is also evidence that higher coffee consumption is associated with lower rates of colon and rectal cancer, as well …
Engineering the next generation of CAR-NK immunotherapies.
Biederstädt A, Rezvani K. Biederstädt A, et al. Int J Hematol. 2021 Nov;114(5):554-571. doi: 10.1007/s12185-021-03209-4. Epub 2021 Aug 28. Int J Hematol. 2021. PMID: 34453686 Free PMC article. Review.
Severely polarized extracellular acidity around tumour cells.
Feng Q, Bennett Z, Grichuk A, Pantoja R, Huang T, Faubert B, Huang G, Chen M, DeBerardinis RJ, Sumer BD, Gao J. Feng Q, et al. Nat Biomed Eng. 2024 Jun;8(6):787-799. doi: 10.1038/s41551-024-01178-7. Epub 2024 Mar 4. Nat Biomed Eng. 2024. PMID: 38438799
Extracellular pH impacts many molecular, cellular and physiological processes, and hence is tightly regulated. Yet, in tumours, dysregulated cancer cell metabolism and poor vascular perfusion cause the tumour microenvironment to become acidic. ...Severely spatially polariz …
Extracellular pH impacts many molecular, cellular and physiological processes, and hence is tightly regulated. Yet, in tumours, dysregulated …
RNA sequestration in P-bodies sustains myeloid leukaemia.
Kodali S, Proietti L, Valcarcel G, López-Rubio AV, Pessina P, Eder T, Shi J, Jen A, Lupión-Garcia N, Starner AC, Bartels MD, Cui Y, Sands CM, Planas-Riverola A, Martínez A, Velasco-Hernandez T, Tomás-Daza L, Alber B, Manhart G, Mayer IM, Kollmann K, Fatica A, Menendez P, Shishkova E, Rau RE, Javierre BM, Coon J, Chen Q, Van Nostrand EL, Sardina JL, Grebien F, Di Stefano B. Kodali S, et al. Nat Cell Biol. 2024 Oct;26(10):1745-1758. doi: 10.1038/s41556-024-01489-6. Epub 2024 Aug 21. Nat Cell Biol. 2024. PMID: 39169219
Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through genome-wide CRISPR screens in normal …
Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we …
Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant Non-Small Cell Lung Cancer.
Araujo HA, Pechuan-Jorge X, Zhou T, Do MT, Hu X, Rojas Alvarez FR, Salvatierra ME, Ibarguen HP, Lee R, Raghulan R, Shah H, Moreno Ayala MA, Chen K, Tovbis Shifrin N, Wu S, Solis Soto LM, Negrao MV, Gibbons DL, Hong DS, Roth JA, Heymach JV, Zhang J, Jiang J, Singh M, Smith JAM, Quintana E, Skoulidis F. Araujo HA, et al. Cancer Discov. 2024 Nov 1;14(11):2183-2208. doi: 10.1158/2159-8290.CD-24-0421. Cancer Discov. 2024. PMID: 38975897
Here, we evaluated the antitumor activity of the RAS(ON) multiselective tricomplex inhibitor RMC-7977 and dissected mechanisms of response and tolerance in KRASG12C-mutant non-small cell lung cancer (NSCLC). Broad-spectrum reversible RASGTP inhibition with or without concu …
Here, we evaluated the antitumor activity of the RAS(ON) multiselective tricomplex inhibitor RMC-7977 and dissected mechanisms of response a …
Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1.
Rodarte KE, Nir Heyman S, Guo L, Flores L, Savage TK, Villarreal J, Deng S, Xu L, Shah RB, Oliver TG, Johnson JE. Rodarte KE, et al. Cancer Res. 2024 Nov 4;84(21):3522-3537. doi: 10.1158/0008-5472.CAN-24-1388. Cancer Res. 2024. PMID: 39264686
Consequently, a portion of these patients develop AR-independent neuroendocrine (NE) prostate cancer (NEPC), a rapidly progressing cancer with limited therapies and poor survival outcomes. ...This study provides an in vivo model to study progression to NEPC and esta …
Consequently, a portion of these patients develop AR-independent neuroendocrine (NE) prostate cancer (NEPC), a rapidly progressing …
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers.
Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B. Lei G, et al. Cancer Discov. 2024 Aug 2;14(8):1476-1495. doi: 10.1158/2159-8290.CD-23-1220. Cancer Discov. 2024. PMID: 38552003
Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) limits the therapeutic efficacy of PARP inhibition in treating breast cancer susceptibility gene 1 (BRCA1)-deficient cancers. Here we reveal that BRCA1 has a dual role in regulating ferroptosis. ...NCOA4 …
Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) limits the therapeutic efficacy of PARP inhibition in treating breast cance …
Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers.
Liao C, Glodowski CR, Fan C, Liu J, Mott KR, Kaushik A, Vu H, Locasale JW, McBrayer SK, DeBerardinis RJ, Perou CM, Zhang Q. Liao C, et al. Cancer Res. 2022 Feb 15;82(4):665-680. doi: 10.1158/0008-5472.CAN-21-2745. Cancer Res. 2022. PMID: 34911787 Free PMC article.
Metabolic dysregulation is a prominent feature in breast cancer, but it remains poorly characterized in patient tumors. In this study, untargeted metabolomics analysis of triple-negative breast cancer (TNBC) and patient with estrogen receptor (ER)-positive breast …
Metabolic dysregulation is a prominent feature in breast cancer, but it remains poorly characterized in patient tumors. In this study …
755 results