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Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

Molloy SS, Bresnahan PA, Leppla SH, Klimpel KR, Thomas G. Molloy SS, et al. J Biol Chem. 1992 Aug 15;267(23):16396-402. J Biol Chem. 1992. PMID: 1644824 Free article.

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.

Klimpel KR, Molloy SS, Thomas G, Leppla SH. Klimpel KR, et al. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10277-81. doi: 10.1073/pnas.89.21.10277. Proc Natl Acad Sci U S A. 1992. PMID: 1438214 Free PMC article.

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