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Page 1
Abatacept in B7-1-positive proteinuric kidney disease.
Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW 3rd, Mundel P. Yu CC, et al. N Engl J Med. 2013 Dec 19;369(25):2416-23. doi: 10.1056/NEJMoa1304572. Epub 2013 Nov 8. N Engl J Med. 2013. PMID: 24206430 Free PMC article.
Dendrin ablation prolongs life span by delaying kidney failure.
Weins A, Wong JS, Basgen JM, Gupta R, Daehn I, Casagrande L, Lessman D, Schwartzman M, Meliambro K, Patrakka J, Shaw A, Tryggvason K, He JC, Nicholas SB, Mundel P, Campbell KN. Weins A, et al. Am J Pathol. 2015 Aug;185(8):2143-57. doi: 10.1016/j.ajpath.2015.04.011. Epub 2015 Jun 12. Am J Pathol. 2015. PMID: 26073036 Free PMC article.
Inhibition of the TRPC5 ion channel protects the kidney filter.
Schaldecker T, Kim S, Tarabanis C, Tian D, Hakroush S, Castonguay P, Ahn W, Wallentin H, Heid H, Hopkins CR, Lindsley CW, Riccio A, Buvall L, Weins A, Greka A. Schaldecker T, et al. J Clin Invest. 2013 Dec;123(12):5298-309. doi: 10.1172/JCI71165. Epub 2013 Nov 15. J Clin Invest. 2013. PMID: 24231357 Free PMC article.
MAGI-2 scaffold protein is critical for kidney barrier function.
Balbas MD, Burgess MR, Murali R, Wongvipat J, Skaggs BJ, Mundel P, Weins A, Sawyers CL. Balbas MD, et al. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14876-81. doi: 10.1073/pnas.1417297111. Epub 2014 Sep 30. Proc Natl Acad Sci U S A. 2014. PMID: 25271328 Free PMC article.