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Minireview: CNS Mechanisms of Leptin Action.
Flak JN, Myers MG Jr. Flak JN, et al. Mol Endocrinol. 2016 Jan;30(1):3-12. doi: 10.1210/me.2015-1232. Epub 2015 Oct 20. Mol Endocrinol. 2016. PMID: 26484582 Free PMC article. Review.
Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
Cheng W, Gonzalez I, Pan W, Tsang AH, Adams J, Ndoka E, Gordian D, Khoury B, Roelofs K, Evers SS, MacKinnon A, Wu S, Frikke-Schmidt H, Flak JN, Trevaskis JL, Rhodes CJ, Fukada SI, Seeley RJ, Sandoval DA, Olson DP, Blouet C, Myers MG Jr. Cheng W, et al. Cell Metab. 2020 Feb 4;31(2):301-312.e5. doi: 10.1016/j.cmet.2019.12.012. Epub 2020 Jan 16. Cell Metab. 2020. PMID: 31955990 Free PMC article.
Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance.
Flak JN, Patterson CM, Garfield AS, D'Agostino G, Goforth PB, Sutton AK, Malec PA, Wong JT, Germani M, Jones JC, Rajala M, Satin L, Rhodes CJ, Olson DP, Kennedy RT, Heisler LK, Myers MG Jr. Flak JN, et al. Nat Neurosci. 2014 Dec;17(12):1744-1750. doi: 10.1038/nn.3861. Epub 2014 Nov 10. Nat Neurosci. 2014. PMID: 25383904 Free PMC article.
Functional identification of a neurocircuit regulating blood glucose.
Meek TH, Nelson JT, Matsen ME, Dorfman MD, Guyenet SJ, Damian V, Allison MB, Scarlett JM, Nguyen HT, Thaler JP, Olson DP, Myers MG Jr, Schwartz MW, Morton GJ. Meek TH, et al. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2073-82. doi: 10.1073/pnas.1521160113. Epub 2016 Mar 21. Proc Natl Acad Sci U S A. 2016. PMID: 27001850 Free PMC article.
A leptin-regulated circuit controls glucose mobilization during noxious stimuli.
Flak JN, Arble D, Pan W, Patterson C, Lanigan T, Goforth PB, Sacksner J, Joosten M, Morgan DA, Allison MB, Hayes J, Feldman E, Seeley RJ, Olson DP, Rahmouni K, Myers MG Jr. Flak JN, et al. J Clin Invest. 2017 Aug 1;127(8):3103-3113. doi: 10.1172/JCI90147. Epub 2017 Jul 17. J Clin Invest. 2017. PMID: 28714862 Free PMC article.