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Page 1
CD8+ T cell differentiation and dysfunction in cancer.
Philip M, Schietinger A. Philip M, et al. Nat Rev Immunol. 2022 Apr;22(4):209-223. doi: 10.1038/s41577-021-00574-3. Epub 2021 Jul 12. Nat Rev Immunol. 2022. PMID: 34253904 Free PMC article. Review.
An autoimmune stem-like CD8 T cell population drives type 1 diabetes.
Gearty SV, Dündar F, Zumbo P, Espinosa-Carrasco G, Shakiba M, Sanchez-Rivera FJ, Socci ND, Trivedi P, Lowe SW, Lauer P, Mohibullah N, Viale A, DiLorenzo TP, Betel D, Schietinger A. Gearty SV, et al. Nature. 2022 Feb;602(7895):156-161. doi: 10.1038/s41586-021-04248-x. Epub 2021 Nov 30. Nature. 2022. PMID: 34847567 Free PMC article.
TOX is a critical regulator of tumour-specific T cell differentiation.
Scott AC, Dündar F, Zumbo P, Chandran SS, Klebanoff CA, Shakiba M, Trivedi P, Menocal L, Appleby H, Camara S, Zamarin D, Walther T, Snyder A, Femia MR, Comen EA, Wen HY, Hellmann MD, Anandasabapathy N, Liu Y, Altorki NK, Lauer P, Levy O, Glickman MS, Kaye J, Betel D, Philip M, Schietinger A. Scott AC, et al. Nature. 2019 Jul;571(7764):270-274. doi: 10.1038/s41586-019-1324-y. Epub 2019 Jun 17. Nature. 2019. PMID: 31207604 Free PMC article.
Exercise and immunometabolic regulation in cancer.
Koelwyn GJ, Zhuang X, Tammela T, Schietinger A, Jones LW. Koelwyn GJ, et al. Nat Metab. 2020 Sep;2(9):849-857. doi: 10.1038/s42255-020-00277-4. Epub 2020 Sep 14. Nat Metab. 2020. PMID: 32929232 Free PMC article. Review.
Intratumoral immune triads are required for adoptive T cell therapy-mediated elimination of solid tumors.
Espinosa-Carrasco G, Scrivo A, Zumbo P, Dave A, Betel D, Hellmann M, Burt BM, Lee HS, Schietinger A. Espinosa-Carrasco G, et al. bioRxiv [Preprint]. 2023 Jul 3:2023.07.03.547423. doi: 10.1101/2023.07.03.547423. bioRxiv. 2023. Update in: Cancer Cell. 2024 Jul 8;42(7):1202-1216.e8. doi: 10.1016/j.ccell.2024.05.025. PMID: 37461721 Free PMC article. Updated. Preprint.
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion.
Shakiba M, Zumbo P, Espinosa-Carrasco G, Menocal L, Dündar F, Carson SE, Bruno EM, Sanchez-Rivera FJ, Lowe SW, Camara S, Koche RP, Reuter VP, Socci ND, Whitlock B, Tamzalit F, Huse M, Hellmann MD, Wells DK, Defranoux NA, Betel D, Philip M, Schietinger A. Shakiba M, et al. J Exp Med. 2022 Feb 7;219(2):e20201966. doi: 10.1084/jem.20201966. Epub 2021 Dec 22. J Exp Med. 2022. PMID: 34935874 Free PMC article.