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Page 1
Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.
Lennox AL, Hoye ML, Jiang R, Johnson-Kerner BL, Suit LA, Venkataramanan S, Sheehan CJ, Alsina FC, Fregeau B, Aldinger KA, Moey C, Lobach I, Afenjar A, Babovic-Vuksanovic D, Bézieau S, Blackburn PR, Bunt J, Burglen L, Campeau PM, Charles P, Chung BHY, Cogné B, Curry C, D'Agostino MD, Di Donato N, Faivre L, Héron D, Innes AM, Isidor B, Keren B, Kimball A, Klee EW, Kuentz P, Küry S, Martin-Coignard D, Mirzaa G, Mignot C, Miyake N, Matsumoto N, Fujita A, Nava C, Nizon M, Rodriguez D, Blok LS, Thauvin-Robinet C, Thevenon J, Vincent M, Ziegler A, Dobyns W, Richards LJ, Barkovich AJ, Floor SN, Silver DL, Sherr EH. Lennox AL, et al. Neuron. 2020 May 6;106(3):404-420.e8. doi: 10.1016/j.neuron.2020.01.042. Epub 2020 Mar 4. Neuron. 2020. PMID: 32135084 Free PMC article.
RNA molecular recording with an engineered RNA deaminase.
Lin Y, Kwok S, Hein AE, Thai BQ, Alabi Y, Ostrowski MS, Wu K, Floor SN. Lin Y, et al. Nat Methods. 2023 Dec;20(12):1887-1899. doi: 10.1038/s41592-023-02046-z. Epub 2023 Oct 19. Nat Methods. 2023. PMID: 37857907 Free PMC article.
A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response.
Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido EH, Kwok S, Chalkley RJ, Li KH, Krogan NJ, Swaney DL, Burlingame AL, Floor SN, Sil A, Walter P, Mukherjee S. Subramanian A, et al. Nat Cell Biol. 2023 Nov;25(11):1600-1615. doi: 10.1038/s41556-023-01248-z. Epub 2023 Oct 19. Nat Cell Biol. 2023. PMID: 37857833 Free PMC article.
DDX3X and DDX3Y are redundant in protein synthesis.
Venkataramanan S, Gadek M, Calviello L, Wilkins K, Floor SN. Venkataramanan S, et al. RNA. 2021 Dec;27(12):1577-1588. doi: 10.1261/rna.078926.121. Epub 2021 Sep 17. RNA. 2021. PMID: 34535544 Free PMC article.
Control of ribosomal protein synthesis by the Microprocessor complex.
Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A. Jiang X, et al. Sci Signal. 2021 Feb 23;14(671):eabd2639. doi: 10.1126/scisignal.abd2639. Sci Signal. 2021. PMID: 33622983 Free PMC article.
DDX3 depletion represses translation of mRNAs with complex 5' UTRs.
Calviello L, Venkataramanan S, Rogowski KJ, Wyler E, Wilkins K, Tejura M, Thai B, Krol J, Filipowicz W, Landthaler M, Floor SN. Calviello L, et al. Nucleic Acids Res. 2021 May 21;49(9):5336-5350. doi: 10.1093/nar/gkab287. Nucleic Acids Res. 2021. PMID: 33905506 Free PMC article.
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