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Somatic p16(INK4a) loss accelerates melanomagenesis.
Monahan KB, Rozenberg GI, Krishnamurthy J, Johnson SM, Liu W, Bradford MK, Horner J, Depinho RA, Sharpless NE. Monahan KB, et al. Oncogene. 2010 Oct 28;29(43):5809-17. doi: 10.1038/onc.2010.314. Epub 2010 Aug 9. Oncogene. 2010. PMID: 20697345 Free PMC article.
CD200 is induced by ERK and is a potential therapeutic target in melanoma.
Petermann KB, Rozenberg GI, Zedek D, Groben P, McKinnon K, Buehler C, Kim WY, Shields JM, Penland S, Bear JE, Thomas NE, Serody JS, Sharpless NE. Petermann KB, et al. J Clin Invest. 2007 Dec;117(12):3922-9. doi: 10.1172/JCI32163. J Clin Invest. 2007. PMID: 18008004 Free PMC article.