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Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization.
Forbes S, Bond AR, Thirlwell KL, Burgoyne P, Samuel K, Noble J, Borthwick G, Colligan D, McGowan NWA, Lewis PS, Fraser AR, Mountford JC, Carter RN, Morton NM, Turner ML, Graham GJ, Campbell JDM. Forbes S, et al. Sci Transl Med. 2020 Jan 15;12(526):eaan5907. doi: 10.1126/scitranslmed.aan5907. Sci Transl Med. 2020. PMID: 31941825 Free article.
Pancreas-derived mesenchymal stromal cells share immune response-modulating and angiogenic potential with bone marrow mesenchymal stromal cells and can be grown to therapeutic scale under Good Manufacturing Practice conditions.
Thirlwell KL, Colligan D, Mountford JC, Samuel K, Bailey L, Cuesta-Gomez N, Hewit KD, Kelly CJ, West CC, McGowan NWA, Casey JJ, Graham GJ, Turner ML, Forbes S, Campbell JDM. Thirlwell KL, et al. Cytotherapy. 2020 Dec;22(12):762-771. doi: 10.1016/j.jcyt.2020.07.010. Epub 2020 Aug 20. Cytotherapy. 2020. PMID: 32828673 Free article.
Fibroblast growth factor 7 releasing particles enhance islet engraftment and improve metabolic control following islet transplantation in mice with diabetes.
Alwahsh SM, Qutachi O, Starkey Lewis PJ, Bond A, Noble J, Burgoyne P, Morton N, Carter R, Mann J, Ferreira-Gonzalez S, Alvarez-Paino M, Forbes SJ, Shakesheff KM, Forbes S. Alwahsh SM, et al. Am J Transplant. 2021 Sep;21(9):2950-2963. doi: 10.1111/ajt.16488. Epub 2021 Feb 2. Am J Transplant. 2021. PMID: 33428803 Free PMC article.