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Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Phelps GA, Cheramie MN, Fernando DM, Selchow P, Meyer CJ, Waidyarachchi SL, Dharuman S, Liu J, Meuli M, Molin MD, Killam BY, Murphy PA, Reeve SM, Wilt LA, Anderson SM, Yang L, Lee RB, Temrikar ZH, Lukka PB, Meibohm B, Polikanov YS, Hobbie SN, Böttger EC, Sander P, Lee RE. Phelps GA, et al. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2314101120. doi: 10.1073/pnas.2314101120. Epub 2024 Jan 2. Proc Natl Acad Sci U S A. 2024. PMID: 38165935 Free PMC article.
Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.
Dharuman S, Phelps GA, Dunn CM, Wilt LA, Murphy PA, Lee RB, Snoke HE, Selchow P, Haldimann K, Böttger EC, Hobbie SN, Sander P, Lee RE. Dharuman S, et al. J Antibiot (Tokyo). 2024 Sep;77(9):577-588. doi: 10.1038/s41429-024-00750-2. Epub 2024 Jun 18. J Antibiot (Tokyo). 2024. PMID: 38890386 Free PMC article.