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A virally encoded tRNA neutralizes the PARIS antiviral defence system.
Burman N, Belukhina S, Depardieu F, Wilkinson RA, Skutel M, Santiago-Frangos A, Graham AB, Livenskyi A, Chechenina A, Morozova N, Zahl T, Henriques WS, Buyukyoruk M, Rouillon C, Saudemont B, Shyrokova L, Kurata T, Hauryliuk V, Severinov K, Groseille J, Thierry A, Koszul R, Tesson F, Bernheim A, Bikard D, Wiedenheft B, Isaev A. Burman N, et al. Nature. 2024 Oct;634(8033):424-431. doi: 10.1038/s41586-024-07874-3. Epub 2024 Aug 7. Nature. 2024. PMID: 39111359 Free PMC article.
Viral proteins activate PARIS-mediated tRNA degradation and viral tRNAs rescue infection.
Burman N, Belukhina S, Depardieu F, Wilkinson RA, Skutel M, Santiago-Frangos A, Graham AB, Livenskyi A, Chechenina A, Morozova N, Zahl T, Henriques WS, Buyukyoruk M, Rouillon C, Shyrokova L, Kurata T, Hauryliuk V, Severinov K, Groseille J, Thierry A, Koszul R, Tesson F, Bernheim A, Bikard D, Wiedenheft B, Isaev A. Burman N, et al. bioRxiv [Preprint]. 2024 Jan 9:2024.01.02.573894. doi: 10.1101/2024.01.02.573894. bioRxiv. 2024. PMID: 38260645 Free PMC article. Preprint.