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Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer.
Bader JE, Enos RT, Velázquez KT, Carson MS, Nagarkatti M, Nagarkatti PS, Chatzistamou I, Davis JM, Carson JA, Robinson CM, Murphy EA. Bader JE, et al. Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G22-G31. doi: 10.1152/ajpgi.00229.2017. Epub 2017 Oct 12. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 29025731 Free PMC article.
Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model.
Velázquez KT, Enos RT, Carson MS, Cranford TL, Bader JE, Chatzistamou I, Singh UP, Nagarkatti PS, Nagarkatti M, Davis JM, Carson JA, Murphy EA. Velázquez KT, et al. Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G699-G712. doi: 10.1152/ajpgi.00207.2016. Epub 2016 Sep 8. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 27609769 Free PMC article.
High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages.
Bader J, Carson M, Enos R, Velazquez K, Sougiannis A, Singh U, Becker W, Nagarkatti M, Fan D, Murphy A. Bader J, et al. Oncotarget. 2020 Dec 8;11(49):4554-4569. doi: 10.18632/oncotarget.27832. eCollection 2020 Dec 8. Oncotarget. 2020. PMID: 33346251 Free PMC article.