G0600069/MRC_/Medical Research Council/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2007	2
2009	1
2011	4
2012	2
2014	1
2025	0

1

A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis.

Holden NJ, Savage CO, Young SP, Wakelam MJ, Harper L, Williams JM. Holden NJ, et al. Mol Med. 2011;17(11-12):1242-52. doi: 10.2119/molmed.2011.00028. Epub 2011 Aug 8. Mol Med. 2011. PMID: 21833457 Free PMC article.

2

ANCA-stimulated neutrophils release BLyS and promote B cell survival: a clinically relevant cellular process.

Holden NJ, Williams JM, Morgan MD, Challa A, Gordon J, Pepper RJ, Salama AD, Harper L, Savage CO. Holden NJ, et al. Ann Rheum Dis. 2011 Dec;70(12):2229-33. doi: 10.1136/ard.2011.153890. Epub 2011 Aug 21. Ann Rheum Dis. 2011. PMID: 21859691

3

PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells.

Tull SP, Bevins A, Kuravi SJ, Satchell SC, Al-Ani B, Young SP, Harper L, Williams JM, Rainger GE, Savage CO. Tull SP, et al. PLoS One. 2012;7(8):e43916. doi: 10.1371/journal.pone.0043916. Epub 2012 Aug 29. PLoS One. 2012. PMID: 22952809 Free PMC article.

4

ANCA-associated vasculitis is linked to carriage of the Z allele of α₁ antitrypsin and its polymers.

Morris H, Morgan MD, Wood AM, Smith SW, Ekeowa UI, Herrmann K, Holle JU, Guillevin L, Lomas DA, Perez J, Pusey CD, Salama AD, Stockley R, Wieczorek S, McKnight AJ, Maxwell AP, Miranda E, Williams J, Savage CO, Harper L. Morris H, et al. Ann Rheum Dis. 2011 Oct;70(10):1851-6. doi: 10.1136/ard.2011.153569. Epub 2011 Aug 5. Ann Rheum Dis. 2011. PMID: 21821620

5

Chimeric IgG4 PR3-ANCA induces selective inflammatory responses from neutrophils through engagement of Fcgamma receptors.

Hussain A, Pankhurst T, Goodall M, Colman R, Jefferis R, Savage CO, Williams JM. Hussain A, et al. Immunology. 2009 Oct;128(2):236-44. doi: 10.1111/j.1365-2567.2009.03108.x. Immunology. 2009. PMID: 19740380 Free PMC article.

6

Chimeric antibodies to proteinase 3 of IgG1 and IgG3 subclasses induce different magnitudes of functional responses in neutrophils.

Colman R, Hussain A, Goodall M, Young SP, Pankhurst T, Lu X, Jefferis R, Savage CO, Williams JM. Colman R, et al. Ann Rheum Dis. 2007 May;66(5):676-82. doi: 10.1136/ard.2006.061374. Epub 2007 Jan 4. Ann Rheum Dis. 2007. PMID: 17204568 Free PMC article.

7

Neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction.

Kuravi SJ, Bevins A, Satchell SC, Harper L, Williams JM, Rainger GE, Savage CO, Tull SP. Kuravi SJ, et al. Nephrol Dial Transplant. 2012 Dec;27(12):4331-8. doi: 10.1093/ndt/gfs180. Epub 2012 Jul 10. Nephrol Dial Transplant. 2012. PMID: 22785107

8

Immunoglobulin subclass determines ability of immunoglobulin (Ig)G to capture and activate neutrophils presented as normal human IgG or disease-associated anti-neutrophil cytoplasm antibody (ANCA)-IgG.

Pankhurst T, Nash G, Williams J, Colman R, Hussain A, Savage C. Pankhurst T, et al. Clin Exp Immunol. 2011 May;164(2):218-26. doi: 10.1111/j.1365-2249.2011.04367.x. Epub 2011 Mar 10. Clin Exp Immunol. 2011. PMID: 21391987 Free PMC article.

9

Podocytes regulate neutrophil recruitment by glomerular endothelial cells via IL-6-mediated crosstalk.

Kuravi SJ, McGettrick HM, Satchell SC, Saleem MA, Harper L, Williams JM, Rainger GE, Savage CO. Kuravi SJ, et al. J Immunol. 2014 Jul 1;193(1):234-43. doi: 10.4049/jimmunol.1300229. Epub 2014 May 28. J Immunol. 2014. PMID: 24872191 Free PMC article. Clinical Trial.

10

Antineutrophil cytoplasm antibody-stimulated neutrophil adhesion depends on diacylglycerol kinase-catalyzed phosphatidic acid formation.

Williams JM, Pettitt TR, Powell W, Grove J, Savage CO, Wakelam MJ. Williams JM, et al. J Am Soc Nephrol. 2007 Apr;18(4):1112-20. doi: 10.1681/ASN.2006090973. Epub 2007 Mar 14. J Am Soc Nephrol. 2007. PMID: 17360949

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