Abstract
The endmost chromosome I ORF is silenced by a natural telomere position effect. YAR073W/IMD1 was found to be transcribed at much higher levels in sir3 mutants and when its adjacent telomere was removed from it. These results suggest that telomeres play a role in silencing actual genes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Base Sequence
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Chromosomes, Fungal / genetics*
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DNA, Fungal / genetics
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Gene Silencing*
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Genes, Fungal
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Mutation
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Open Reading Frames
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Saccharomyces cerevisiae / genetics*
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Silent Information Regulator Proteins, Saccharomyces cerevisiae / genetics
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Telomere / genetics*
Substances
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DNA, Fungal
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SIR3 protein, S cerevisiae
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Silent Information Regulator Proteins, Saccharomyces cerevisiae