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Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.
Halpert I, Sires UI, Roby JD, Potter-Perigo S, Wight TN, Shapiro SD, Welgus HG, Wickline SA, Parks WC. Halpert I, et al. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9748-53. doi: 10.1073/pnas.93.18.9748. Proc Natl Acad Sci U S A. 1996. PMID: 8790402 Free PMC article.