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Early elevated IFNα is a key mediator of HIV pathogenesis.
Buanec HL, Schiavon V, Merandet M, How-Kit A, Bergerat D, Fombellida-Lopez C, Bensussan A, Bouaziz JD, Burny A, Darcis G, Song H, Sajadi MM, Kottilil S, Gallo RC, Zagury D. Buanec HL, et al. Commun Med (Lond). 2024 Mar 19;4(1):53. doi: 10.1038/s43856-024-00454-6. Commun Med (Lond). 2024. PMID: 38504106 Free PMC article.
IFNα induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation.
Le Buanec H, Schiavon V, Merandet M, How-Kit A, Song H, Bergerat D, Fombellida-Lopez C, Bensussan A, Bouaziz JD, Burny A, Darcis G, Sajadi MM, Kottilil S, Zagury D, Gallo RC. Le Buanec H, et al. Commun Med (Lond). 2024 Mar 19;4(1):52. doi: 10.1038/s43856-024-00453-7. Commun Med (Lond). 2024. PMID: 38504093 Free PMC article.
Performance of nucleocapsid and spike-based SARS-CoV-2 serologic assays.
Rikhtegaran Tehrani Z, Saadat S, Saleh E, Ouyang X, Constantine N, DeVico AL, Harris AD, Lewis GK, Kottilil S, Sajadi MM. Rikhtegaran Tehrani Z, et al. PLoS One. 2020 Nov 2;15(11):e0237828. doi: 10.1371/journal.pone.0237828. eCollection 2020. PLoS One. 2020. PMID: 33137138 Free PMC article.
Combined cART including Tenofovir Disoproxil, Emtricitabine, and Dolutegravir has potent therapeutic effects in HIV-1 infected humanized mice.
Weichseldorfer M, Affram Y, Heredia A, Rikhtegaran-Tehrani Z, Sajadi MM, Williams SP, Tagaya Y, Benedetti F, Ramadhani HO, Denaro F, Munawwar A, Bryant J, Zella D, Reitz M, Romerio F, Latinovic OS. Weichseldorfer M, et al. J Transl Med. 2021 Oct 30;19(1):453. doi: 10.1186/s12967-021-03120-w. J Transl Med. 2021. PMID: 34717655 Free PMC article.
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.
Sajadi MM, Abbasi A, Tehrani ZR, Siska C, Clark R, Chi W, Seaman MS, Mielke D, Wagh K, Liu Q, Jumpa T, Ketchem RR, Nguyen DN, Tolbert WD, Pierce BG, Atkinson B, Deming D, Sprague M, Asakawa A, Ferrer D, Dunn Y, Calvillo S, Yin R, Guest JD, Korber B, Mayer BT, Sato AH, Ouyang X, Foulke S, Habibzadeh P, Karimi M, Aslanabadi A, Hojabri M, Saadat S, Zareidoodeji R, Kędzior M, Pozharski E, Heredia A, Montefiori D, Ferrari G, Pazgier M, Lewis GK, Jardine JG, Lusso P, DeVico A. Sajadi MM, et al. bioRxiv [Preprint]. 2024 Oct 17:2024.10.14.618178. doi: 10.1101/2024.10.14.618178. bioRxiv. 2024. PMID: 39464103 Free PMC article. Preprint.
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