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Year Number of Results
2016 1
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165 results

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Page 1
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer.
Enfield KSS, Colliver E, Lee C, Magness A, Moore DA, Sivakumar M, Grigoriadis K, Pich O, Karasaki T, Hobson PS, Levi D, Veeriah S, Puttick C, Nye EL, Green M, Dijkstra KK, Shimato M, Akarca AU, Marafioti T, Salgado R, Hackshaw A; TRACERx consortium; Jamal-Hanjani M, van Maldegem F, McGranahan N, Glass B, Pulaski H, Walk E, Reading JL, Quezada SA, Hiley CT, Downward J, Sahai E, Swanton C, Angelova M. Enfield KSS, et al. Cancer Discov. 2024 Jun 3;14(6):1018-1047. doi: 10.1158/2159-8290.CD-23-1380. Cancer Discov. 2024. PMID: 38581685 Free PMC article.
Understanding the role of the tumor microenvironment (TME) in lung cancer is critical to improving patient outcomes. We identified four histology-independent archetype TMEs in treatment-naive early-stage lung cancer using imaging mass cytometry in the TRACERx study …
Understanding the role of the tumor microenvironment (TME) in lung cancer is critical to improving patient outcomes. We identified fo …
Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency.
Kohn DB, Booth C, Shaw KL, Xu-Bayford J, Garabedian E, Trevisan V, Carbonaro-Sarracino DA, Soni K, Terrazas D, Snell K, Ikeda A, Leon-Rico D, Moore TB, Buckland KF, Shah AJ, Gilmour KC, De Oliveira S, Rivat C, Crooks GM, Izotova N, Tse J, Adams S, Shupien S, Ricketts H, Davila A, Uzowuru C, Icreverzi A, Barman P, Campo Fernandez B, Hollis RP, Coronel M, Yu A, Chun KM, Casas CE, Zhang R, Arduini S, Lynn F, Kudari M, Spezzi A, Zahn M, Heimke R, Labik I, Parrott R, Buckley RH, Reeves L, Cornetta K, Sokolic R, Hershfield M, Schmidt M, Candotti F, Malech HL, Thrasher AJ, Gaspar HB. Kohn DB, et al. N Engl J Med. 2021 May 27;384(21):2002-2013. doi: 10.1056/NEJMoa2027675. Epub 2021 May 11. N Engl J Med. 2021. PMID: 33974366 Free PMC article. Clinical Trial.
CONCLUSIONS: Treatment of ADA-SCID with ex vivo lentiviral HSPC gene therapy resulted in high overall and event-free survival with sustained ADA expression, metabolic correction, and functional immune reconstitution. (Funded by the National Institutes of Health and …
CONCLUSIONS: Treatment of ADA-SCID with ex vivo lentiviral HSPC gene therapy resulted in high overall and event-free survival with sustained …
Metastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer.
Fujino S, Miyoshi N, Ito A, Hayashi R, Yasui M, Matsuda C, Ohue M, Horie M, Yachida S, Koseki J, Shimamura T, Hata T, Ogino T, Takahashi H, Uemura M, Mizushima T, Doki Y, Eguchi H. Fujino S, et al. Commun Biol. 2023 Nov 24;6(1):1191. doi: 10.1038/s42003-023-05562-y. Commun Biol. 2023. PMID: 37996567 Free PMC article.
However, which cells comprise the complex tumor lineages in recurrence and are key in metastasis are unknown in colorectal cancer (CRC). CRC with high expression of POU5F1 has a poor prognosis with a high incidence of liver metastatic recurrence. ...Sorted POU5F1-expressin …
However, which cells comprise the complex tumor lineages in recurrence and are key in metastasis are unknown in colorectal cancer (CR …
Immunomodulation in Pancreatic Cancer.
Krishnamoorthy M, Lenehan JG, Burton JP, Maleki Vareki S. Krishnamoorthy M, et al. Cancers (Basel). 2020 Nov 12;12(11):3340. doi: 10.3390/cancers12113340. Cancers (Basel). 2020. PMID: 33198059 Free PMC article. Review.
Pancreatic cancer has a high mortality rate, and its incidence is increasing worldwide. The almost universal poor prognosis of pancreatic cancer is partly due to symptoms presenting only at late stages and limited effective treatments. ...Unfortunately, these therap …
Pancreatic cancer has a high mortality rate, and its incidence is increasing worldwide. The almost universal poor prognosis of pancre …
Clinical and Translational Significance of Basophils in Patients with Cancer.
Chauhan J, Stavraka C, Grandits M, Palhares LCGF, Josephs DH, Lacy KE, Spicer J, Bax HJ, Karagiannis SN. Chauhan J, et al. Cells. 2022 Jan 27;11(3):438. doi: 10.3390/cells11030438. Cells. 2022. PMID: 35159247 Free PMC article. Review.
While their activation states and functions can be influenced by Th2-biased inflammatory signals, which are also known features of several tumor types, basophils have received little attention in cancer. Here, we discuss the presence and functional significance of basophil …
While their activation states and functions can be influenced by Th2-biased inflammatory signals, which are also known features of several t …
Multifactorial Remodeling of the Cancer Immunopeptidome by IFNgamma.
Newey A, Yu L, Barber LJ, Choudhary JS, Bassani-Sternberg M, Gerlinger M. Newey A, et al. Cancer Res Commun. 2023 Nov 17;3(11):2345-2357. doi: 10.1158/2767-9764.CRC-23-0121. Cancer Res Commun. 2023. PMID: 37991387 Free PMC article.
IFNgamma alters the immunopeptidome presented on HLA class I (HLA-I), and its activity on cancer cells is known to be important for effective immunotherapy responses. We performed proteomic analyses of untreated and IFNgamma-treated colorectal cancer patient-derived …
IFNgamma alters the immunopeptidome presented on HLA class I (HLA-I), and its activity on cancer cells is known to be important for e …
Stiffness reconstruction methods for MR elastography.
Fovargue D, Nordsletten D, Sinkus R. Fovargue D, et al. NMR Biomed. 2018 Oct;31(10):e3935. doi: 10.1002/nbm.3935. Epub 2018 May 18. NMR Biomed. 2018. PMID: 29774974 Free PMC article. Review.
Magnetic resonance elastography (MRE) provides an avenue for measuring tissue stiffness and has a long history of clinical application, including staging liver fibrosis and stratifying breast cancer malignancy. A vital component of MRE consists of the reconstruction algori …
Magnetic resonance elastography (MRE) provides an avenue for measuring tissue stiffness and has a long history of clinical application, incl …
Unravelling undifferentiated soft tissue sarcomas: insights from genomics.
Hames-Fathi S, Nottley SWG, Pillay N. Hames-Fathi S, et al. Histopathology. 2022 Jan;80(1):109-121. doi: 10.1111/his.14446. Histopathology. 2022. PMID: 34958500 Review.
Undifferentiated pleomorphic sarcoma now falls under the broader rubric of undifferentiated soft tissue sarcoma (USTS) in the 2020 World Health Organization classification of bone and soft tissue tumours. These rare cancers remain a diagnosis of exclusion, and show genomic …
Undifferentiated pleomorphic sarcoma now falls under the broader rubric of undifferentiated soft tissue sarcoma (USTS) in the 2020 World …
Effects of senescence on the tumour microenvironment and response to therapy.
Reynolds LE, Maallin S, Haston S, Martinez-Barbera JP, Hodivala-Dilke KM, Pedrosa AR. Reynolds LE, et al. FEBS J. 2024 Jun;291(11):2306-2319. doi: 10.1111/febs.16984. Epub 2023 Nov 1. FEBS J. 2024. PMID: 37873605 Review.
It is associated with profound changes in gene expression and a specific secretory profile that includes pro-inflammatory cytokines, growth factors and matrix-remodelling enzymes, referred to as the senescence-associated secretory phenotype (SASP). In cancer, senescence ca …
It is associated with profound changes in gene expression and a specific secretory profile that includes pro-inflammatory cytokines, growth …
IgE Antibodies against Cancer: Efficacy and Safety.
Chauhan J, McCraw AJ, Nakamura M, Osborn G, Sow HS, Cox VF, Stavraka C, Josephs DH, Spicer JF, Karagiannis SN, Bax HJ. Chauhan J, et al. Antibodies (Basel). 2020 Oct 16;9(4):55. doi: 10.3390/antib9040055. Antibodies (Basel). 2020. PMID: 33081206 Free PMC article. Review.
165 results