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Absence of a reductase, NCB5OR, causes insulin-deficient diabetes.
Xie J, Zhu H, Larade K, Ladoux A, Seguritan A, Chu M, Ito S, Bronson RT, Leiter EH, Zhang CY, Rosen ED, Bunn HF. Xie J, et al. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10750-5. doi: 10.1073/pnas.0404044101. Epub 2004 Jul 9. Proc Natl Acad Sci U S A. 2004. PMID: 15247412 Free PMC article.