Neighborhood deprivation and clinical outcomes among head and neck cancer patients

Health Place. 2012 Jul;18(4):861-8. doi: 10.1016/j.healthplace.2012.03.005. Epub 2012 Mar 14.

Abstract

The unique effects of neighborhood-level economic deprivation on survival, recurrence, and second primary malignancy development were examined using adjusted Cox proportional hazards regression models among 1151 incident squamous cell carcinomas of the head and neck patients. Cancer site was examined as a potential moderator. Main analyses yielded null results; however, interaction analyses indicated poorer overall survival [HR=1.59 (1.00-2.53)] and greater second primary malignancy development [HR=2.99 (1.46-6.11)] among oropharyngeal cancer patients from highly deprived neighborhoods relative to less deprived neighborhoods. Results suggest a dual focus on individual and neighborhood risk factors could help improve clinical outcomes among oropharyngeal cancer patients.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Epidemiologic Studies
  • Female
  • Head and Neck Neoplasms / mortality*
  • Head and Neck Neoplasms / pathology
  • Health Status Disparities
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / mortality*
  • Neoplasms, Second Primary / pathology
  • Outcome Assessment, Health Care
  • Poverty
  • Proportional Hazards Models
  • Residence Characteristics*
  • Retrospective Studies
  • Risk Factors
  • Social Class
  • Survival Analysis