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Whole-genome doubling confers unique genetic vulnerabilities on tumour cells.
Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. Quinton RJ, et al. Nature. 2021 Feb;590(7846):492-497. doi: 10.1038/s41586-020-03133-3. Epub 2021 Jan 27. Nature. 2021. PMID: 33505027 Free PMC article.
Generation and Purification of Tetraploid Cells.
Shenk EM, Ganem NJ. Shenk EM, et al. Methods Mol Biol. 2016;1413:393-401. doi: 10.1007/978-1-4939-3542-0_24. Methods Mol Biol. 2016. PMID: 27193862 Free PMC article.