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Deep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology.
Gustav M, Reitsam NG, Carrero ZI, Loeffler CML, van Treeck M, Yuan T, West NP, Quirke P, Brinker TJ, Brenner H, Favre L, Märkl B, Stenzinger A, Brobeil A, Hoffmeister M, Calderaro J, Pujals A, Kather JN. Gustav M, et al. NPJ Precis Oncol. 2024 May 23;8(1):115. doi: 10.1038/s41698-024-00592-z. NPJ Precis Oncol. 2024. PMID: 38783059 Free PMC article.
Lynch syndrome screening in colorectal cancer: results of a prospective 2-year regional programme validating the NICE diagnostics guidance pathway throughout a 5.2-million population.
West NP, Gallop N, Kaye D, Glover A, Young C, Hutchins GGA, Brockmoeller SF, Westwood AC, Rossington H, Quirke P; Yorkshire Cancer Research Bowel Cancer Improvement Programme Group. West NP, et al. Histopathology. 2021 Nov;79(5):690-699. doi: 10.1111/his.14390. Epub 2021 Jun 21. Histopathology. 2021. PMID: 33872400 Free article.
The ATOM-Seq sequence capture panel can accurately predict microsatellite instability status in formalin-fixed tumour samples, alongside routine gene mutation testing.
Srihar K, Gusnanto A, Richman SD, West NP, Galvin L, Bottomley D, Hemmings G, Glover A, Natarajan S, Miller R, Arif S, Rossington H, Dunwell TL, Dailey SC, Fontarum G, George A, Wu W, Quirke P, Wood HM. Srihar K, et al. Sci Rep. 2024 Sep 19;14(1):21870. doi: 10.1038/s41598-024-72419-7. Sci Rep. 2024. PMID: 39300198 Free PMC article.