MOP-142378/CIHR/Canada[Grants and Funding] - Search Results

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Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice.

Miyata KN, Lo CS, Zhao S, Liao MC, Pang Y, Chang SY, Peng J, Kretzler M, Filep JG, Ingelfinger JR, Zhang SL, Chan JSD. Miyata KN, et al. Clin Sci (Lond). 2021 Apr 16;135(7):943-961. doi: 10.1042/CS20210094. Clin Sci (Lond). 2021. PMID: 33822013 Free PMC article.

Overexpression of Nrf2 in Renal Proximal Tubular Cells Stimulates Sodium-Glucose Cotransporter 2 Expression and Exacerbates Dysglycemia and Kidney Injury in Diabetic Mice.

Zhao S, Lo CS, Miyata KN, Ghosh A, Zhao XP, Chenier I, Cailhier JF, Ethier J, Lattouf JB, Filep JG, Ingelfinger JR, Zhang SL, Chan JSD. Zhao S, et al. Diabetes. 2021 Jun;70(6):1388-1403. doi: 10.2337/db20-1126. Epub 2021 Apr 5. Diabetes. 2021. PMID: 33820760

Deletion of heterogeneous nuclear ribonucleoprotein F in renal tubules downregulates SGLT2 expression and attenuates hyperfiltration and kidney injury in a mouse model of diabetes.

Miyata KN, Lo CS, Zhao S, Zhao XP, Chenier I, Yamashita M, Filep JG, Ingelfinger JR, Zhang SL, Chan JSD. Miyata KN, et al. Diabetologia. 2021 Nov;64(11):2589-2601. doi: 10.1007/s00125-021-05538-9. Epub 2021 Aug 9. Diabetologia. 2021. PMID: 34370045 Free PMC article.

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