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Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis.
Jarvis JN, Lawrence DS, Meya DB, Kagimu E, Kasibante J, Mpoza E, Rutakingirwa MK, Ssebambulidde K, Tugume L, Rhein J, Boulware DR, Mwandumba HC, Moyo M, Mzinganjira H, Kanyama C, Hosseinipour MC, Chawinga C, Meintjes G, Schutz C, Comins K, Singh A, Muzoora C, Jjunju S, Nuwagira E, Mosepele M, Leeme T, Siamisang K, Ndhlovu CE, Hlupeni A, Mutata C, van Widenfelt E, Chen T, Wang D, Hope W, Boyer-Chammard T, Loyse A, Molloy SF, Youssouf N, Lortholary O, Lalloo DG, Jaffar S, Harrison TS; Ambition Study Group. Jarvis JN, et al. N Engl J Med. 2022 Mar 24;386(12):1109-1120. doi: 10.1056/NEJMoa2111904. N Engl J Med. 2022. PMID: 35320642 Free PMC article. Clinical Trial.
Cryptococcal meningoencephalitis: time for action.
Stott KE, Loyse A, Jarvis JN, Alufandika M, Harrison TS, Mwandumba HC, Day JN, Lalloo DG, Bicanic T, Perfect JR, Hope W. Stott KE, et al. Lancet Infect Dis. 2021 Sep;21(9):e259-e271. doi: 10.1016/S1473-3099(20)30771-4. Epub 2021 Apr 16. Lancet Infect Dis. 2021. PMID: 33872594 Review.
Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis.
Giamberardino CD, Tenor JL, Toffaletti DL, Palmucci JR, Schell W, Boua J-VK, Marius C, Stott KE, Steele SL, Hope W, Cilla D, Perfect JR. Giamberardino CD, et al. Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0081823. doi: 10.1128/aac.00818-23. Epub 2023 Sep 20. Antimicrob Agents Chemother. 2023. PMID: 37728934 Free PMC article.
Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis.
Giamberardino CD, Schell WA, Tenor JL, Toffaletti DL, Palmucci JR, Marius C, Boua JK, Soltow Q, Mansbach R, Moseley MA, Thompson JW, Dubois LG, Hope W, Perfect JR, Shaw KJ. Giamberardino CD, et al. mBio. 2022 Dec 20;13(6):e0234722. doi: 10.1128/mbio.02347-22. Epub 2022 Oct 12. mBio. 2022. PMID: 36222509 Free PMC article.
Population pharmacokinetics of liposomal amphotericin B in adults with HIV-associated cryptococcal meningoencephalitis.
Stott KE, Moyo M, Ahmadu A, Kajanga C, Gondwe E, Chimang'anga W, Chasweka M, Leeme TB, Molefi M, Chofle A, Bidwell G, Changalucha J, Unsworth J, Jimenez-Valverde A, Lawrence DS, Mwandumba HC, Lalloo DG, Harrison TS, Jarvis JN, Hope W, Märtson AG. Stott KE, et al. J Antimicrob Chemother. 2022 Dec 23;78(1):276-283. doi: 10.1093/jac/dkac389. J Antimicrob Chemother. 2022. PMID: 36411251 Free PMC article.
Population pharmacokinetics and CSF penetration of flucytosine in adults with HIV-associated cryptococcal meningoencephalitis.
Stott KE, Ahmadu A, Kajanga C, Moyo M, Gondwe E, Chimang'anga W, Chasweka M, Unsworth J, Jimenez-Valverde A, Jagota B, Shah RV, Lawrence DS, Lalloo DG, Harrison T, Jarvis JN, Hope W, Mwandumba HC. Stott KE, et al. J Antimicrob Chemother. 2023 Apr 3;78(4):1015-1022. doi: 10.1093/jac/dkad038. J Antimicrob Chemother. 2023. PMID: 36857467 Free PMC article.
Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease.
Nixon GL, McEntee L, Johnson A, Farrington N, Whalley S, Livermore J, Natal C, Washbourn G, Bibby J, Berry N, Lestner J, Truong M, Owen A, Lalloo D, Charles I, Hope W. Nixon GL, et al. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01909-17. doi: 10.1128/AAC.01909-17. Print 2018 Apr. Antimicrob Agents Chemother. 2018. PMID: 29311092 Free PMC article.
Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus-associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial.
Jarvis JN, Leeme TB, Molefi M, Chofle AA, Bidwell G, Tsholo K, Tlhako N, Mawoko N, Patel RKK, Tenforde MW, Muthoga C, Bisson GP, Kidola J, Changalucha J, Lawrence D, Jaffar S, Hope W, Molloy SLF, Harrison TS. Jarvis JN, et al. Clin Infect Dis. 2019 Jan 18;68(3):393-401. doi: 10.1093/cid/ciy515. Clin Infect Dis. 2019. PMID: 29945252 Free PMC article. Clinical Trial.