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mTOR and ROS regulation by anethole on adipogenic differentiation in human mesenchymal stem cells.
Rhee YH, Moon JH, Mo JH, Pham T, Chung PS. Rhee YH, et al. BMC Cell Biol. 2018 Jul 6;19(1):12. doi: 10.1186/s12860-018-0163-2. BMC Cell Biol. 2018. PMID: 29980168 Free PMC article.
The western blotting was used to detect of phospho-Akt, phospho-mTOR, phospho-p70S6K, PPARgamma, and phsopho-AMP-activated kinase (AMPK). RESULTS: Anethole suppressed the adipogenic differentiation of hMSCs through down-regulation of Akt-mTOR-p70S6K-PPARgamma and up-regula …
The western blotting was used to detect of phospho-Akt, phospho-mTOR, phospho-p70S6K, PPARgamma, and phsopho-AMP-activated kinase (AM …
Structural insight into molecular mechanism of cytokinin activating protein from Pseudomonas aeruginosa PAO1.
Seo H, Kim KJ. Seo H, et al. Environ Microbiol. 2018 Sep;20(9):3214-3223. doi: 10.1111/1462-2920.14287. Epub 2018 Aug 8. Environ Microbiol. 2018. PMID: 29901273
The overall structure of PA4923 resembles those of type-I LOGs, and it exhibited phosphoribohydrolase activity against AMP. These observations indicated that PA4923 functions as an LOG. We also determined the PaLOG structure in complex with AMP and elucidated the de …
The overall structure of PA4923 resembles those of type-I LOGs, and it exhibited phosphoribohydrolase activity against AMP. These obs …
The orphan nuclear receptor NR4A1 promotes FcεRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis.
Jin F, Li X, Deng Y, Timilshina M, Huang B, Kim DY, Chang JH, Ichinose H, Baek SH, Murakami M, Lee YJ, Chang HW. Jin F, et al. Allergy. 2019 Jun;74(6):1145-1156. doi: 10.1111/all.13702. Epub 2019 Jan 4. Allergy. 2019. PMID: 30565708
Mechanistically, NR4A1 promoted FcepsilonRI signaling by counteracting the liver kinase B1 (LKB1)/adenosine monophosphate-activated protein kinase (AMPK) axis. Following FcepsilonRI crosslinking, NR4A1 bound to the LKB1/AMPK complex and sequestered it in the nucleus …
Mechanistically, NR4A1 promoted FcepsilonRI signaling by counteracting the liver kinase B1 (LKB1)/adenosine monophosphate-acti …