Stem cell imaging: from bench to bedside

Patricia K Nguyen; Johannes Riegler; Joseph C Wu

doi:10.1016/j.stem.2014.03.009

Stem cell imaging: from bench to bedside

Cell Stem Cell. 2014 Apr 3;14(4):431-44. doi: 10.1016/j.stem.2014.03.009.

Authors

Patricia K Nguyen¹, Johannes Riegler¹, Joseph C Wu²

Affiliations

¹ Department of Medicine, Division of Cardiology, Stanford, CA 94305, USA; Department of Radiology, Molecular Imaging Program, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford, CA 94305, USA.
² Department of Medicine, Division of Cardiology, Stanford, CA 94305, USA; Department of Radiology, Molecular Imaging Program, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford, CA 94305, USA; Institute of Stem Cell Biology and Regenerative Medicine, Stanford, CA 94305, USA. Electronic address: [email protected].

Abstract

Although cellular therapies hold great promise for the treatment of human disease, results from several initial clinical trials have not shown a level of efficacy required for their use as a first line therapy. Here we discuss how in vivo molecular imaging has helped identify barriers to clinical translation and potential strategies that may contribute to successful transplantation and improved outcomes, with a focus on cardiovascular and neurological diseases. We conclude with a perspective on the future role of molecular imaging in defining safety and efficacy for clinical implementation of stem cell therapies.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Cardiovascular Diseases / diagnosis
Cardiovascular Diseases / therapy
Cell Tracking / methods*
Cell- and Tissue-Based Therapy*
Humans
Molecular Imaging*
Nervous System Diseases / diagnosis
Nervous System Diseases / therapy
Stem Cell Transplantation*
Stem Cells / cytology*

Abstract

Publication types

MeSH terms

Grants and funding