Abstract
Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Disease Transmission, Infectious
-
Female
-
Gene Products, env* / chemistry
-
Gene Products, env* / genetics
-
Gene Products, env* / metabolism
-
Glycosylation
-
HIV Envelope Protein gp120 / chemistry
-
HIV Envelope Protein gp120 / genetics
-
HIV Envelope Protein gp120 / metabolism
-
HIV Envelope Protein gp160 / chemistry
-
HIV Envelope Protein gp160 / genetics
-
HIV Envelope Protein gp160 / metabolism
-
HIV Infections / transmission*
-
HIV Infections / virology
-
HIV-1 / classification
-
HIV-1 / genetics*
-
HIV-1 / physiology
-
Humans
-
Male
-
Molecular Sequence Data
-
Sequence Analysis, DNA
Substances
-
Gene Products, env
-
HIV Envelope Protein gp120
-
HIV Envelope Protein gp160