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2023 4
2024 3

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A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer.
Antal CE, Oh TG, Aigner S, Luo EC, Yee BA, Campos T, Tiriac H, Rothamel KL, Cheng Z, Jiao H, Wang A, Hah N, Lenkiewicz E, Lumibao JC, Truitt ML, Estepa G, Banayo E, Bashi S, Esparza E, Munoz RM, Diedrich JK, Sodir NM, Mueller JR, Fraser CR, Borazanci E, Propper D, Von Hoff DD, Liddle C, Yu RT, Atkins AR, Han H, Lowy AM, Barrett MT, Engle DD, Evan GI, Yeo GW, Downes M, Evans RM. Antal CE, et al. Nat Commun. 2023 Sep 6;14(1):5195. doi: 10.1038/s41467-023-40798-6. Nat Commun. 2023. PMID: 37673892 Free PMC article.
Inhibiting stromal Class I HDACs curbs pancreatic cancer progression.
Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. Liang G, et al. Nat Commun. 2023 Dec 6;14(1):7791. doi: 10.1038/s41467-023-42178-6. Nat Commun. 2023. PMID: 38057326 Free PMC article.
Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression.
Fu T, Huan T, Rahman G, Zhi H, Xu Z, Oh TG, Guo J, Coulter S, Tripathi A, Martino C, McCarville JL, Zhu Q, Cayabyab F, Low B, He M, Xing S, Vargas F, Yu RT, Atkins A, Liddle C, Ayres J, Raffatellu M, Dorrestein PC, Downes M, Knight R, Evans RM. Fu T, et al. Cell Rep. 2023 Aug 29;42(8):112997. doi: 10.1016/j.celrep.2023.112997. Epub 2023 Aug 22. Cell Rep. 2023. PMID: 37611587 Free PMC article.
Targeting nuclear receptor corepressors for reversible male contraception.
Hong SH, Castro G, Wang D, Nofsinger R, Kane M, Folias A, Atkins AR, Yu RT, Napoli JL, Sassone-Corsi P, de Rooij DG, Liddle C, Downes M, Evans RM. Hong SH, et al. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2320129121. doi: 10.1073/pnas.2320129121. Epub 2024 Feb 20. Proc Natl Acad Sci U S A. 2024. PMID: 38377195 Free PMC article.
Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming.
Yang Y, Zhang X, Cai D, Zheng X, Zhao X, Zou JX, Zhang J, Borowsky AD, Dall'Era MA, Corey E, Mitsiades N, Kung HJ, Chen X, Li JJ, Downes M, Evans RM, Chen HW. Yang Y, et al. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2411321121. doi: 10.1073/pnas.2411321121. Epub 2024 Oct 9. Proc Natl Acad Sci U S A. 2024. PMID: 39383000 Free PMC article.