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Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages.
Askari B, Kanter JE, Sherrid AM, Golej DL, Bender AT, Liu J, Hsueh WA, Beavo JA, Coleman RA, Bornfeldt KE. Askari B, et al. Diabetes. 2007 Apr;56(4):1143-52. doi: 10.2337/db06-0267. Epub 2007 Jan 26. Diabetes. 2007. PMID: 17259370 Free PMC article.
Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition.
Lewin TM, de Jong H, Schwerbrock NJ, Hammond LE, Watkins SM, Combs TP, Coleman RA. Lewin TM, et al. Biochim Biophys Acta. 2008 Jun-Jul;1781(6-7):352-8. doi: 10.1016/j.bbalip.2008.05.001. Epub 2008 May 15. Biochim Biophys Acta. 2008. PMID: 18522808 Free PMC article.