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The controversial world of sirtuins.
Dang W. Dang W. Drug Discov Today Technol. 2014 Jun;12:e9-e17. doi: 10.1016/j.ddtec.2012.08.003. Drug Discov Today Technol. 2014. PMID: 25027380 Free PMC article. Review.
H3K36 methylation promotes longevity by enhancing transcriptional fidelity.
Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL. Sen P, et al. Genes Dev. 2015 Jul 1;29(13):1362-76. doi: 10.1101/gad.263707.115. Genes Dev. 2015. PMID: 26159996 Free PMC article.
Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response.
Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL. Dang W, et al. Cell Metab. 2014 Jun 3;19(6):952-66. doi: 10.1016/j.cmet.2014.04.004. Epub 2014 May 8. Cell Metab. 2014. PMID: 24814484 Free PMC article.
Development of organometallic S6K1 inhibitors.
Qin J, Rajaratnam R, Feng L, Salami J, Barber-Rotenberg JS, Domsic J, Reyes-Uribe P, Liu H, Dang W, Berger SL, Villanueva J, Meggers E, Marmorstein R. Qin J, et al. J Med Chem. 2015 Jan 8;58(1):305-14. doi: 10.1021/jm5011868. Epub 2014 Nov 13. J Med Chem. 2015. PMID: 25356520 Free PMC article.
12 results