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Page 1
Chemical interrogation of the malaria kinome.
Derbyshire ER, Zuzarte-Luís V, Magalhães AD, Kato N, Sanschagrin PC, Wang J, Zhou W, Miduturu CV, Mazitschek R, Sliz P, Mota MM, Gray NS, Clardy J. Derbyshire ER, et al. Chembiochem. 2014 Sep 5;15(13):1920-30. doi: 10.1002/cbic.201400025. Epub 2014 Aug 8. Chembiochem. 2014. PMID: 25111632 Free PMC article.
Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity.
Posfai D, Eubanks AL, Keim AI, Lu KY, Wang GZ, Hughes PF, Kato N, Haystead TA, Derbyshire ER. Posfai D, et al. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01799-17. doi: 10.1128/AAC.01799-17. Print 2018 Apr. Antimicrob Agents Chemother. 2018. PMID: 29339390 Free PMC article.
Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites.
Raphemot R, Eubanks AL, Toro-Moreno M, Geiger RA, Hughes PF, Lu KY, Haystead TAJ, Derbyshire ER. Raphemot R, et al. Cell Chem Biol. 2019 Mar 21;26(3):411-419.e7. doi: 10.1016/j.chembiol.2018.11.003. Epub 2018 Dec 27. Cell Chem Biol. 2019. PMID: 30595530 Free PMC article.
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ Jr, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R. Herman JD, et al. Sci Transl Med. 2015 May 20;7(288):288ra77. doi: 10.1126/scitranslmed.aaa3575. Sci Transl Med. 2015. PMID: 25995223 Free PMC article.
Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.
Totzke J, Gurbani D, Raphemot R, Hughes PF, Bodoor K, Carlson DA, Loiselle DR, Bera AK, Eibschutz LS, Perkins MM, Eubanks AL, Campbell PL, Fox DA, Westover KD, Haystead TAJ, Derbyshire ER. Totzke J, et al. Cell Chem Biol. 2017 Aug 17;24(8):1029-1039.e7. doi: 10.1016/j.chembiol.2017.07.011. Cell Chem Biol. 2017. PMID: 28820959 Free PMC article.