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Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis.
J Neuropathol Exp Neurol. 2024 May 22;83(6):396-415. doi: 10.1093/jnen/nlae032.
J Neuropathol Exp Neurol. 2024.
PMID: 38613823
Free PMC article.
Review.
In severe ADNC, hippocampi with comorbid LATE-NC and hippocampal sclerosis have substantially more astrocytosis than those with LATE-NC or hippocampal sclerosis alone.
Niedowicz DM, Katsumata Y, Nelson PT.
Niedowicz DM, et al.
J Neuropathol Exp Neurol. 2023 Nov 20;82(12):987-994. doi: 10.1093/jnen/nlad085.
J Neuropathol Exp Neurol. 2023.
PMID: 37935530
Free PMC article.
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The epidemiology is promising, but the trial evidence is weak. Why pharmacological dementia risk reduction trials haven't lived up to expectations, and where do we go from here?
Peters R, Dodge HH, James S, Jicha GA, Meyer PF, Richards M, Smith AD, Yassine HN, Abner E, Hainsworth AH, Kehoe PG, Beckett N, Anderson CS, Anstey KJ.
Peters R, et al.
Alzheimers Dement. 2022 Mar;18(3):507-512. doi: 10.1002/alz.12393. Epub 2021 Nov 2.
Alzheimers Dement. 2022.
PMID: 34726352
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