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Strategies for Targeting Senescent Cells in Human Disease.
Gasek NS, Kuchel GA, Kirkland JL, Xu M. Gasek NS, et al. Nat Aging. 2021 Oct;1(10):870-879. doi: 10.1038/s43587-021-00121-8. Epub 2021 Oct 7. Nat Aging. 2021. PMID: 34841261 Free PMC article. Review.
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2.
Chaib S, López-Domínguez JA, Lalinde-Gutiérrez M, Prats N, Marin I, Boix O, García-Garijo A, Meyer K, Muñoz MI, Aguilera M, Mateo L, Stephan-Otto Attolini C, Llanos S, Pérez-Ramos S, Escorihuela M, Al-Shahrour F, Cash TP, Tchkonia T, Kirkland JL, Abad M, Gros A, Arribas J, Serrano M. Chaib S, et al. Nat Cancer. 2024 Mar;5(3):448-462. doi: 10.1038/s43018-023-00712-x. Epub 2024 Jan 24. Nat Cancer. 2024. PMID: 38267628 Free PMC article.
Targeting cellular senescence in metabolic disease.
Palmer AK, Tchkonia T, Kirkland JL. Palmer AK, et al. Mol Metab. 2022 Dec;66:101601. doi: 10.1016/j.molmet.2022.101601. Epub 2022 Sep 16. Mol Metab. 2022. PMID: 36116755 Free PMC article. Review.
Role of senescence in the chronic health consequences of COVID-19.
Wissler Gerdes EO, Vanichkachorn G, Verdoorn BP, Hanson GJ, Joshi AY, Murad MH, Rizza SA, Hurt RT, Tchkonia T, Kirkland JL. Wissler Gerdes EO, et al. Transl Res. 2022 Mar;241:96-108. doi: 10.1016/j.trsl.2021.10.003. Epub 2021 Oct 22. Transl Res. 2022. PMID: 34695606 Free PMC article. Review.
12 results