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Alzheimer's disease risk allele of PICALM causes detrimental lipid droplets in microglia.
Kozlova A, Zhang S, Sudwarts A, Zhang H, Smirnou S, Sun X, Stephenson K, Zhao X, Jamison B, Ponnusamy M, He X, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, Duan J. Kozlova A, et al. Res Sq [Preprint]. 2024 May 24:rs.3.rs-4407146. doi: 10.21203/rs.3.rs-4407146/v1. Res Sq. 2024. PMID: 38826437 Free PMC article. Preprint.
Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model.
Li X, Liu J, Boreland AJ, Kapadia S, Zhang S, Stillitano AC, Abbo Y, Clark L, Lai D, Liu Y, Barr PB, Meyers JL, Kamarajan C, Kuang W, Agrawal A, Slesinger PA, Dick D, Salvatore J, Tischfield J, Duan J, Edenberg HJ, Kreimer A, Hart RP, Pang ZP. Li X, et al. Sci Adv. 2024 Nov 8;10(45):eado5820. doi: 10.1126/sciadv.ado5820. Epub 2024 Nov 8. Sci Adv. 2024. PMID: 39514655 Free PMC article.
Scaled and efficient derivation of loss-of-function alleles in risk genes for neurodevelopmental and psychiatric disorders in human iPSCs.
Zhang H, McCarroll A, Peyton L, Díaz de León-Guerrerro S, Zhang S, Gowda P, Sirkin D, ElAchwah M, Duhe A, Wood WG, Jamison B, Tracy G, Pollak R, Hart RP, Pato CN, Mulle JG, Sanders AR, Pang ZP, Duan J. Zhang H, et al. Stem Cell Reports. 2024 Oct 8;19(10):1489-1504. doi: 10.1016/j.stemcr.2024.08.003. Epub 2024 Sep 12. Stem Cell Reports. 2024. PMID: 39270650 Free PMC article.