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Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma.
Newcomb DC, Cephus JY, Boswell MG, Fahrenholz JM, Langley EW, Feldman AS, Zhou W, Dulek DE, Goleniewska K, Woodward KB, Sevin CM, Hamilton RG, Kolls JK, Peebles RS Jr. Newcomb DC, et al. J Allergy Clin Immunol. 2015 Oct;136(4):1025-34.e11. doi: 10.1016/j.jaci.2015.05.046. Epub 2015 Aug 1. J Allergy Clin Immunol. 2015. PMID: 26242299 Free PMC article. Clinical Trial.
Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling.
Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS Jr. Zhou W, et al. J Allergy Clin Immunol. 2014 Sep;134(3):698-705.e5. doi: 10.1016/j.jaci.2014.06.004. Epub 2014 Jul 18. J Allergy Clin Immunol. 2014. PMID: 25042746 Free PMC article.