Abstract
The synthesis and evaluation for iNKT stimulation of alpha-S-galactosylceramide is reported. Prepared by alkylation of a galactosylthiol, this analog of the potent immunostimulatory agent, KRN7000, did not stimulate iNKT cells either in vitro or in vivo.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / pharmacology
-
Chemistry, Pharmaceutical / methods
-
Drug Design
-
Galactosylceramides / chemical synthesis*
-
Galactosylceramides / chemistry*
-
Galactosylceramides / pharmacology*
-
Glycolipids / chemistry
-
Humans
-
Hydrogen Bonding
-
Killer Cells, Natural / drug effects
-
Killer Cells, Natural / immunology*
-
Models, Chemical
-
Oxygen / chemistry
-
Solubility
-
Sulfhydryl Compounds / chemistry
Substances
-
Antineoplastic Agents
-
Galactosylceramides
-
Glycolipids
-
Sulfhydryl Compounds
-
alpha-galactosylceramide
-
Oxygen
-
KRN 7000