R01 AI093967/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2011	5
2012	7
2013	7
2014	8
2015	4
2017	2
2018	1
2024	0

1

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Sun L, Wu J, Du F, Chen X, Chen ZJ. Sun L, et al. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012 Dec 20. Science. 2013. PMID: 23258413 Free PMC article.

2

Innate immune sensing and signaling of cytosolic nucleic acids.

Wu J, Chen ZJ. Wu J, et al. Annu Rev Immunol. 2014;32:461-88. doi: 10.1146/annurev-immunol-032713-120156. Annu Rev Immunol. 2014. PMID: 24655297 Review.

3

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.

Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ. Wu J, et al. Science. 2013 Feb 15;339(6121):826-30. doi: 10.1126/science.1229963. Epub 2012 Dec 20. Science. 2013. PMID: 23258412 Free PMC article.

4

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.

Liu S, Cai X, Wu J, Cong Q, Chen X, Li T, Du F, Ren J, Wu YT, Grishin NV, Chen ZJ. Liu S, et al. Science. 2015 Mar 13;347(6227):aaa2630. doi: 10.1126/science.aaa2630. Epub 2015 Jan 29. Science. 2015. PMID: 25636800

5

STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.

Tanaka Y, Chen ZJ. Tanaka Y, et al. Sci Signal. 2012 Mar 6;5(214):ra20. doi: 10.1126/scisignal.2002521. Sci Signal. 2012. PMID: 22394562 Free PMC article.

6

A STING-activating nanovaccine for cancer immunotherapy.

Luo M, Wang H, Wang Z, Cai H, Lu Z, Li Y, Du M, Huang G, Wang C, Chen X, Porembka MR, Lea J, Frankel AE, Fu YX, Chen ZJ, Gao J. Luo M, et al. Nat Nanotechnol. 2017 Jul;12(7):648-654. doi: 10.1038/nnano.2017.52. Epub 2017 Apr 24. Nat Nanotechnol. 2017. PMID: 28436963 Free PMC article.

7

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects.

Li XD, Wu J, Gao D, Wang H, Sun L, Chen ZJ. Li XD, et al. Science. 2013 Sep 20;341(6152):1390-4. doi: 10.1126/science.1244040. Epub 2013 Aug 29. Science. 2013. PMID: 23989956 Free PMC article.

8

MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.

Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ. Hou F, et al. Cell. 2011 Aug 5;146(3):448-61. doi: 10.1016/j.cell.2011.06.041. Epub 2011 Jul 21. Cell. 2011. PMID: 21782231 Free PMC article.

9

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Rongvaux A, et al. Cell. 2014 Dec 18;159(7):1563-77. doi: 10.1016/j.cell.2014.11.037. Cell. 2014. PMID: 25525875 Free PMC article.

10

Intrinsic antiviral immunity.

Yan N, Chen ZJ. Yan N, et al. Nat Immunol. 2012 Feb 16;13(3):214-22. doi: 10.1038/ni.2229. Nat Immunol. 2012. PMID: 22344284 Free PMC article. Review.

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