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Page 1
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity.
Prinzing B, Zebley CC, Petersen CT, Fan Y, Anido AA, Yi Z, Nguyen P, Houke H, Bell M, Haydar D, Brown C, Boi SK, Alli S, Crawford JC, Riberdy JM, Park JJ, Zhou S, Velasquez MP, DeRenzo C, Lazzarotto CR, Tsai SQ, Vogel P, Pruett-Miller SM, Langfitt DM, Gottschalk S, Youngblood B, Krenciute G. Prinzing B, et al. Sci Transl Med. 2021 Nov 17;13(620):eabh0272. doi: 10.1126/scitranslmed.abh0272. Epub 2021 Nov 17. Sci Transl Med. 2021. PMID: 34788079 Free PMC article.
Effector CD8 T cells dedifferentiate into long-lived memory cells.
Youngblood B, Hale JS, Kissick HT, Ahn E, Xu X, Wieland A, Araki K, West EE, Ghoneim HE, Fan Y, Dogra P, Davis CW, Konieczny BT, Antia R, Cheng X, Ahmed R. Youngblood B, et al. Nature. 2017 Dec 21;552(7685):404-409. doi: 10.1038/nature25144. Epub 2017 Dec 13. Nature. 2017. PMID: 29236683 Free PMC article.
Stem, Effector, and Hybrid States of Memory CD8+ T Cells.
Lugli E, Galletti G, Boi SK, Youngblood BA. Lugli E, et al. Trends Immunol. 2020 Jan;41(1):17-28. doi: 10.1016/j.it.2019.11.004. Epub 2019 Dec 4. Trends Immunol. 2020. PMID: 31810790 Free PMC article. Review.
Conserved epigenetic hallmarks of T cell aging during immunity and malignancy.
Mi T, Soerens AG, Alli S, Kang TG, Vasandan AB, Wang Z, Vezys V, Kimura S, Iacobucci I, Baylin SB, Jones PA, Hiner C, Mueller A, Goldstein H, Mullighan CG, Zebley CC, Masopust D, Youngblood B. Mi T, et al. Nat Aging. 2024 Aug;4(8):1053-1063. doi: 10.1038/s43587-024-00649-5. Epub 2024 Jun 12. Nat Aging. 2024. PMID: 38867059 Free PMC article.
Memory CD8 T cell transcriptional plasticity.
Youngblood B, Hale JS, Ahmed R. Youngblood B, et al. F1000Prime Rep. 2015 Apr 1;7:38. doi: 10.12703/P7-38. eCollection 2015. F1000Prime Rep. 2015. PMID: 26097712 Free PMC article. Review.
Cell-Intrinsic Barriers of T Cell-Based Immunotherapy.
Ghoneim HE, Zamora AE, Thomas PG, Youngblood BA. Ghoneim HE, et al. Trends Mol Med. 2016 Dec;22(12):1000-1011. doi: 10.1016/j.molmed.2016.10.002. Epub 2016 Nov 4. Trends Mol Med. 2016. PMID: 27825667 Free PMC article. Review.
21 results