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Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies.
Parthasarathy D, Pothula KR, Dam KA, Ratnapriya S, Benet HC, Parsons R, Huang X, Sammour S, Janowska K, Harris M, Sacco S, Sodroski J, Bridges MD, Hubbell WL, Acharya P, Herschhorn A. Parthasarathy D, et al. bioRxiv [Preprint]. 2023 Dec 5:2023.09.13.557082. doi: 10.1101/2023.09.13.557082. bioRxiv. 2023. Update in: Nat Commun. 2024 Aug 26;15(1):7334. doi: 10.1038/s41467-024-51656-4 PMID: 37745449 Free PMC article. Updated. Preprint.
Alternative substitutions of N332 in HIV-1AD8 gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting the V3-glycan.
Jeffy J, Parthasarathy D, Ahmed S, Cervera-Benet H, Xiong U, Harris M, Mazurov D, Pickthorn S, Herschhorn A. Jeffy J, et al. bioRxiv [Preprint]. 2023 Nov 21:2023.11.20.567910. doi: 10.1101/2023.11.20.567910. bioRxiv. 2023. Update in: mBio. 2024 Apr 10;15(4):e0268623. doi: 10.1128/mbio.02686-23 PMID: 38045336 Free PMC article. Updated. Preprint.