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Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Woo SR, Turnis ME, Goldberg MV, Bankoti J, Selby M, Nirschl CJ, Bettini ML, Gravano DM, Vogel P, Liu CL, Tangsombatvisit S, Grosso JF, Netto G, Smeltzer MP, Chaux A, Utz PJ, Workman CJ, Pardoll DM, Korman AJ, Drake CG, Vignali DA. Woo SR, et al. Cancer Res. 2012 Feb 15;72(4):917-27. doi: 10.1158/0008-5472.CAN-11-1620. Epub 2011 Dec 20. Cancer Res. 2012. PMID: 22186141 Free PMC article.
Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3.
Bettini M, Szymczak-Workman AL, Forbes K, Castellaw AH, Selby M, Pan X, Drake CG, Korman AJ, Vignali DA. Bettini M, et al. J Immunol. 2011 Oct 1;187(7):3493-8. doi: 10.4049/jimmunol.1100714. Epub 2011 Aug 26. J Immunol. 2011. PMID: 21873518 Free PMC article.
The plasticity of regulatory T cell function.
Pillai MR, Collison LW, Wang X, Finkelstein D, Rehg JE, Boyd K, Szymczak-Workman AL, Doggett T, Griffith TS, Ferguson TA, Vignali DA. Pillai MR, et al. J Immunol. 2011 Nov 15;187(10):4987-97. doi: 10.4049/jimmunol.1102173. Epub 2011 Oct 17. J Immunol. 2011. PMID: 22013112 Free PMC article.