R01 CA050434/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

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2000	1
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The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral.

Osei-Sarfo K, Martello L, Ibrahim S, Pellicer A. Osei-Sarfo K, et al. Oncogene. 2011 Aug 25;30(34):3661-71. doi: 10.1038/onc.2011.93. Epub 2011 Mar 28. Oncogene. 2011. PMID: 21441953 Free PMC article.

Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b).

Malumbres M, Pérez De Castro I, Hernández MI, Jiménez M, Corral T, Pellicer A. Malumbres M, et al. Mol Cell Biol. 2000 Apr;20(8):2915-25. doi: 10.1128/MCB.20.8.2915-2925.2000. Mol Cell Biol. 2000. PMID: 10733595 Free PMC article.

Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.

Perez de Castro I, Bivona TG, Philips MR, Pellicer A. Perez de Castro I, et al. Mol Cell Biol. 2004 Apr;24(8):3485-96. doi: 10.1128/MCB.24.8.3485-3496.2004. Mol Cell Biol. 2004. PMID: 15060167 Free PMC article.

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