R01 CA051210-17/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

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Subject: R01 CA051210-17/CA/NCI NIH HHS/United States[Gran - PubMed

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Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1).

Yan C, Kepa JK, Siegel D, Stratford IJ, Ross D. Yan C, et al. Mol Pharmacol. 2008 Dec;74(6):1657-65. doi: 10.1124/mol.108.050401. Epub 2008 Sep 15. Mol Pharmacol. 2008. PMID: 18794327 Free PMC article.

Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action.

Guo W, Reigan P, Siegel D, Ross D. Guo W, et al. Drug Metab Dispos. 2008 Oct;36(10):2050-7. doi: 10.1124/dmd.108.022004. Epub 2008 Jul 17. Drug Metab Dispos. 2008. PMID: 18635747 Free PMC article.

Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation.

Guo W, Siegel D, Ross D. Guo W, et al. J Pharm Sci. 2008 Dec;97(12):5147-57. doi: 10.1002/jps.21394. J Pharm Sci. 2008. PMID: 18393300 Free PMC article.

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