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A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma.
Kumthekar P, Ko CH, Paunesku T, Dixit K, Sonabend AM, Bloch O, Tate M, Schwartz M, Zuckerman L, Lezon R, Lukas RV, Jovanovic B, McCortney K, Colman H, Chen S, Lai B, Antipova O, Deng J, Li L, Tommasini-Ghelfi S, Hurley LA, Unruh D, Sharma NV, Kandpal M, Kouri FM, Davuluri RV, Brat DJ, Muzzio M, Glass M, Vijayakumar V, Heidel J, Giles FJ, Adams AK, James CD, Woloschak GE, Horbinski C, Stegh AH. Kumthekar P, et al. Sci Transl Med. 2021 Mar 10;13(584):eabb3945. doi: 10.1126/scitranslmed.abb3945. Sci Transl Med. 2021. PMID: 33692132 Free PMC article. Clinical Trial.
Hairpin-like siRNA-Based Spherical Nucleic Acids.
Vasher MK, Yamankurt G, Mirkin CA. Vasher MK, et al. J Am Chem Soc. 2022 Feb 23;144(7):3174-3181. doi: 10.1021/jacs.1c12750. Epub 2022 Feb 10. J Am Chem Soc. 2022. PMID: 35143189 Free PMC article.
Multi-antigen spherical nucleic acid cancer vaccines.
Teplensky MH, Evangelopoulos M, Dittmar JW, Forsyth CM, Sinegra AJ, Wang S, Mirkin CA. Teplensky MH, et al. Nat Biomed Eng. 2023 Jul;7(7):911-927. doi: 10.1038/s41551-022-01000-2. Epub 2023 Jan 30. Nat Biomed Eng. 2023. PMID: 36717738 Free PMC article.
Sequence Multiplicity within Spherical Nucleic Acids.
Huang ZN, Cole LE, Callmann CE, Wang S, Mirkin CA. Huang ZN, et al. ACS Nano. 2020 Jan 28;14(1):1084-1092. doi: 10.1021/acsnano.9b08750. Epub 2020 Jan 9. ACS Nano. 2020. PMID: 31917535 Free PMC article.
IDH3α regulates one-carbon metabolism in glioblastoma.
May JL, Kouri FM, Hurley LA, Liu J, Tommasini-Ghelfi S, Ji Y, Gao P, Calvert AE, Lee A, Chandel NS, Davuluri RV, Horbinski CM, Locasale JW, Stegh AH. May JL, et al. Sci Adv. 2019 Jan 2;5(1):eaat0456. doi: 10.1126/sciadv.aat0456. eCollection 2019 Jan. Sci Adv. 2019. PMID: 30613765 Free PMC article.
In Vivo Behavior of Ultrasmall Spherical Nucleic Acids.
Callmann CE, Vasher MK, Das A, Kusmierz CD, Mirkin CA. Callmann CE, et al. Small. 2023 Jun;19(24):e2300097. doi: 10.1002/smll.202300097. Epub 2023 Mar 11. Small. 2023. PMID: 36905236 Free PMC article.
21 results