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Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis.
Izzo LT, Trefely S, Demetriadou C, Drummond JM, Mizukami T, Kuprasertkul N, Farria AT, Nguyen PTT, Murali N, Reich L, Kantner DS, Shaffer J, Affronti H, Carrer A, Andrews A, Capell BC, Snyder NW, Wellen KE. Izzo LT, et al. Sci Adv. 2023 May 3;9(18):eadf0115. doi: 10.1126/sciadv.adf0115. Epub 2023 May 3. Sci Adv. 2023. PMID: 37134161 Free PMC article.
αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation.
Uboveja A, Huang Z, Buj R, Amalric A, Wang H, Tangudu NK, Cole AR, Megill E, Kantner D, Chatoff A, Ahmad H, Marcinkiewicz MM, Disharoon JA, Graff S, Dahl ES, Hempel N, Stallaert W, Sidoli S, Bitler BG, Long DT, Snyder NW, Aird KM. Uboveja A, et al. bioRxiv [Preprint]. 2024 Feb 11:2024.02.06.578742. doi: 10.1101/2024.02.06.578742. bioRxiv. 2024. PMID: 38370789 Free PMC article. Preprint.
De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression.
Tangudu NK, Buj R, Wang H, Wang J, Cole AR, Uboveja A, Fang R, Amalric A, Yang B, Chatoff A, Crispim CV, Sajjakulnukit P, Lyons MA, Cooper K, Hempel N, Lyssiotis CA, Chandran UR, Snyder NW, Aird KM. Tangudu NK, et al. Cancer Res Commun. 2024 May 2;4(5):1174-1188. doi: 10.1158/2767-9764.CRC-23-0450. Cancer Res Commun. 2024. PMID: 38626341 Free PMC article.
ATM inhibition drives metabolic adaptation via induction of macropinocytosis.
Huang Z, Chen CW, Buj R, Tangudu NK, Fang RS, Leon KE, Dahl ES, Varner EL, von Krusenstiern E, Cole AR, Snyder NW, Aird KM. Huang Z, et al. J Cell Biol. 2023 Jan 2;222(1):e202007026. doi: 10.1083/jcb.202007026. Epub 2022 Nov 18. J Cell Biol. 2023. PMID: 36399181 Free PMC article.
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